Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products > 

Histamine phosphate

Related Products

Others Products

Basic Information post buying leads Suppliers
Name Histamine phosphate EINECS 200-118-4
CAS No. 51-74-1 Density
Solubility Melting Point
Formula C5H9N3.2(H3PO4) Boiling Point 331 °C at 760 mmHg
Molecular Weight 307.13 Flash Point 180.3 °C
Transport Information Appearance White crystal powder
Safety Risk Codes
Molecular Structure Molecular Structure of 51-74-1 (Histamine phosphate) Hazard Symbols
Synonyms

Histamine acid phosphate;1H-Imidazole-4-ethanamine,compounds,phosphate (1:2);Histamine Diphosphate;Histamine bisphosphate monohydrate;

 

Chemistry

Molecular Structure of Histamine phosphate (CAS NO.51-74-1):

Molecular Formula C5H9N3.2(H3PO4)
Molecular Weight 307.13
IUPAC Name: 2-(1H-Imidazol-5-yl)ethanamine; phosphoric acid 
Synonyms of Histamine phosphate (CAS NO.51-74-1): Histamine phosphate [USP] ; 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate) ;  4-(2-Aminoethyl)imidazole di-acid phosphate ; EINECS 200-118-4 ; Histamine acid phosphate ; Histamine biphosphate ; Histamine dihydrogen phosphate ; Histamine diphosphate ; Histamine phosphate (1:2) ; Histamine positive ; UNII-QWB37T4WZZ ; 1H-Imidazole-4-ethanamine, phosphate (1:2) ; 2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
CAS NO: 51-74-1
Classification Code: Histamine Agents ; Neurotransmitter Agents ; Reproductive Effect ; Stimulant [gastric secretory] Stimulant [gastric secretory]
Flash Point: 180.3 °C
Enthalpy of Vaporization: 57.36 kJ/mol
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25°C
nChI
InChI=1/C5H9N3.2H3O4P/c6-2-1-5-3-7-4-8-5;2*1-5(2,3)4/h3-4H,1-2,6H2,(H,7,8);2*(H3,1,2,3,4)
Download | View Full InChI
Smiles
[nH]1cnc(CCN)c1.P(O)(=O)(O)O.P(O)(=O)(O)O
Classification Code: Histamine Agents; Neurotransmitter Agents; Reproductive Effect; Stimulant

Uses

 Histamine phosphate (CAS NO.51-74-1) has been used for the presumptive diagnosis of pheochromocytoma; however, the use of histamine in patients suspected of having pheochromocytoma is hazardous and unwarranted due to the risk of precipitating a hypertensive crisis. Histamine phosphate has been used to produce short-term improvement in patients with vertigo, tinnitus, and deafness. However, it has not been proven effective in the symptomatic treatment of Menière's disease.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 608ug/kg (0.608mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Journal of Pharmaceutical Sciences. Vol. 57, Pg. 1543, 1968.
guinea pig LDLo parenteral 746ug/kg (0.746mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1574, 1970.
mouse LD50 intraperitoneal 913mg/kg (913mg/kg)   Journal of Pharmaceutical Sciences. Vol. 59, Pg. 1659, 1970.
mouse LD50 intravenous 333mg/kg (333mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 90, Pg. 726, 1955.
mouse LD50 oral 807mg/kg (807mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 122, Pg. 685, 1966.
rabbit LD50 intravenous 2763ug/kg (2.763mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 299, 1942.
rabbit LDLo parenteral 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.
rat LD50 intraperitoneal 1781mg/kg (1781mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.
rat LDLo intravenous 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

A deadly poison by intravenous and parenteral routes. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NOx and POx.

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields