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Name	Indeloxazine hydrochloride	EINECS	N/A
CAS No.	65043-22-3	Density	N/A
PSA	30.49000	LogP	2.75390
Solubility	N/A	Melting Point	169-170°; mp 155-156°
Formula	C14H17 N O2 . Cl H	Boiling Point	401.4°C at 760 mmHg
Molecular Weight	267.755	Flash Point	160.3°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Morpholine,2-[(1H-inden-7-yloxy)methyl]-, hydrochloride (9CI); CI 874; Elen; Indeloxazinehydrochloride; Noin; YM 08054; YM 08054-1	Article Data	2

Indeloxazine hydrochloride Synthetic route

: 64966-73-0
(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 17h; Heating;	73.4%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 30190-85-3
1-(inden-7-yloxy)-2,3-epoxypropane

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In methanol 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;	73%

: 60929-58-0
(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 2: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 40987-24-4
R,S-2-hydroxymethyl-4-benzylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature 2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature 3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

Yield

Multi-step reaction with 6 steps
1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature
2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme

: 103003-01-6
morpholin-2-ylmethanol

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature 2: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 3: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 4: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 5: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 131965-77-0
(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 2: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 3: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 4: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 60929-57-9
2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 2: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 3: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 60929-60-4
4-morpholin-2-ylmethoxy-indan-1-ol

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride In ethanol; chloroform; acetone

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

: 65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2
(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

Conditions

Conditions	Yield
Yield given;

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

: 65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2
(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

Conditions

Conditions	Yield
Yield given;

Indeloxazine hydrochloride Chemical Properties

Product Name: Indeloxazine hydrochloride
CAS Registry Number: 65043-22-3
IUPAC Name: 2-(3H-inden-4-yloxymethyl)morpholine hydrochloride
Molecular Weight: 267.75122 [g/mol]
Molecular Formula: C₁₄H₁₈ClNO₂
H-Bond Donor: 2
H-Bond Acceptor: 3
Flash Point: 160.3 °C
Enthalpy of Vaporization: 65.24 kJ/mol
Boiling Point: 401.4 °C at 760 mmHg
Vapour Pressure: 1.18E-06 mmHg at 25°C
Following is the molecular structure of Indeloxazine hydrochloride (CAS NO.65043-22-3) is:

Indeloxazine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 60mg/kg (60mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse	LD50	intraperitoneal	50400ug/kg (50.4mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1181, 1988.
mouse	LD50	intravenous	47mg/kg (47mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 238, Pg. 81, 1979.
mouse	LD50	oral	340mg/kg (340mg/kg)		United States Patent Document. Vol. #4297356,
mouse	LD50	subcutaneous	245mg/kg (245mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	intravenous	77300ug/kg (77.3mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	oral	502mg/kg (502mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	subcutaneous	206mg/kg (206mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985

Indeloxazine hydrochloride Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Indeloxazine hydrochloride Specification

Indeloxazine hydrochloride , its cas register number is 65043-22-3. It also can be called Indeloxazine hydrochloride [USAN:JAN] ; (+-)-2-((Inden-7-yloxy)methyl)morpholine hydrochloride ; 2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride ; CI 874 ; Indeloxazine HCl ; Indeloxazine hydrochloride ; Morpholine, 2-((1H-inden-7-yloxy)methyl)-, hydrochloride, (+-)- ; UNII-15QZ6NE84E ; YM 08054-1 ; YM-08054-1 .

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