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Cas Database |
| Name |
Naftidrofuryl |
EINECS | 250-572-2 |
| CAS No. | 31329-57-4 | Density | 1.079g/cm3 |
| PSA | 38.77000 | LogP | 4.45260 |
| Solubility | N/A | Melting Point |
80-83°C |
| Formula | C24H33 N O3 | Boiling Point | 518.3°Cat760mmHg |
| Molecular Weight | 383.531 | Flash Point | 267.3°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2-Furanpropionicacid, tetrahydro-a-(1-naphthylmethyl)-,2-(diethylamino)ethyl ester (7CI,8CI);2-(Diethylamino)ethyl tetrahydro-a-(1-naphthylmethyl)-2-furanpropionateester;Gevatran;LS 84;N-Diethylamino ethyl b-(1-naphthol)-b-(2-tetrahydrofuryl)isobutyrate oxolate salt;Nafronyl;Naftidrofuryl;Naphtidrofuryl;Tridus; |
Article Data | 6 |
Naftidrofuryl Chemical Properties
Product Name: Naftidrofuryl (CAS NO.31329-57-4)
Molecular Formula: C24H33NO3
Molecular Weight: 383.52g/mol
Mol File: 31329-57-4.mol
Einecs: 250-572-2
Boiling point: 518.3 °C at 760 mmHg
Flash Point: 267.3 °C
Density: 1.079 g/cm3
Surface Tension: 43.2 dyne/cm
Enthalpy of Vaporization: 79.08 kJ/mol
Vapour Pressure: 7.57E-11 mmHg at 25°C
XLogP3-AA: 4.8
H-Bond Donor: 0
H-Bond Acceptor: 4
Structure Descriptors of Naftidrofuryl (CAS NO.31329-57-4):
IUPAC Name: 2-diethylaminoethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
Canonical SMILES: CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32
InChI: InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3
InChIKey: KBAFPSLPKGSANY-UHFFFAOYSA-N
Naftidrofuryl Uses
Naftidrofuryl (CAS NO.31329-57-4) (INN, also known as nafronyl or as the oxalate salt nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be a 5-HT2 receptor antagonist.
Naftidrofuryl Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 129mg/kg (129mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gendai no Rinsho. Vol. 5, Pg. 1, 1971. |
| mouse | LD50 | intravenous | 23mg/kg (23mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 188, 1975. | |
| mouse | LD50 | oral | 365mg/kg (365mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 10, Pg. 291, 1975. | |
| mouse | LD50 | subcutaneous | 272mg/kg (272mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gendai no Rinsho. Vol. 5, Pg. 1, 1971. |
| rat | LD50 | intraperitoneal | 120mg/kg (120mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gendai no Rinsho. Vol. 5, Pg. 1, 1971. |
| rat | LD50 | oral | 1890mg/kg (1890mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gendai no Rinsho. Vol. 5, Pg. 1, 1971. |
| rat | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gendai no Rinsho. Vol. 5, Pg. 1, 1971. |
Naftidrofuryl Safety Profile
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Naftidrofuryl Specification
Naftidrofuryl ,its CAS NO. is 31329-57-4,the synonyms is 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate ; 3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester ; BRN 1296059 ; EINECS 250-572-2 ; LS 84 ; N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate ; Nafronyl ; Naftidrofurilo ; Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester ; Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester ; Tridus ; UNII-42H8PQ0NMJ ; alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester .
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