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Ondansetron

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Ondansetron

EINECS 619-449-4
CAS No. 99614-02-5 Density 1.27 g/cm3
PSA 39.82000 LogP 3.12850
Solubility N/A Melting Point 231 - 232oC
Formula C18H19N3O Boiling Point 546 °C at 760 mmHg
Molecular Weight 293.368 Flash Point 284 °C
Transport Information UN 2811 6.1/PG 3 Appearance White or almost White Powder
Safety 45-37/39-26 Risk Codes 25-36/37/38
Molecular Structure Molecular Structure of 99614-02-5 (Ondansetron) Hazard Symbols ToxicT,IrritantXi
Synonyms

1,2,3,4-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-9H-carbazol-4-one;GR 38032;GR 38032X;Ondanles;1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazo;Zofran;Zophren;Zudan;

Article Data 30

Ondansetron Chemical Properties

The Molecular formula of Ondansetron (CAS NO.99614-02-5): C18H19N3O   
The Molecular Weight of Ondansetron (CAS NO.99614-02-5): 293.37
The Molecular Structure of Ondansetron (CAS NO.99614-02-5):

Density: 1.27 g/cm3
Boiling point: 546 °C at 760 mmHg 
Flash point: 284 °C   
Solubility in water: H2O: >5 mg/mL
Index of Refraction:1.677 
Molar Refractivity: 86.75 cm
Molar Volume: 230.1 cm3
Surface Tension: 48.9 dyne/cm
Enthalpy of Vaporization: 82.5 kJ/mol   
Vapour Pressure: 5.62E-12 mmHg at 25°
IUPAC Name: 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one hydrochloride  
Synonyms: 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazo ; Gr 38032f  ; Ondansetrone hydrochloride ; Ondansetron hcl ; Ondansetron hcl dihydrate ; Ondansetron hydrochloride dihydrate ; Gr38032

Ondansetron History

Ondansetron was developed around 1984 by scientists working at Glaxo's laboratories in London. It is in both the Imidazole and Carbazole families of heterocyclic compounds.After several attempts the company successfully filed for U.S. patent protection for the drug in 1986. U.S. Patent 4,695,578 was granted in September 1987 while U.S. Patent 4,753,789 was granted in June 1988. U.S. Patent 5,578,628, a divisional patent of U.S. Patent 4,753,789, was granted in November 26, 1996. Ondansetron was granted Food and Drug Administration (FDA) approval as Zofran in January 1991. Glaxo did pediatric research on Zofran's uses, and gained patent extension as a result. Consequently U.S. exclusivity ended December 24, 2006. The FDA subsequently approved the first generic versions in December 2006, with marketing approval granted to Teva Pharmaceuticals USA and SICOR Pharmaceuticals. It is currently marketed by GlaxoSmithKline (GSK) under the trade name Zofran; other manufacturers include Cipla Ltd. (Emeset), Gedeon Richter Ltd. (Emetron), Korea United Pharmaceuticals (Emodan), Zentiva a.s. (Ondemet) and Novell Pharmaceutical Laboratories (Ondavell). On May 29, 2006, Baxter Healthcare received tentative approval to market its own label of Ondansetron Injection, USP, 8 mg/50 mL and 32 mg/50 mL iso-osmotic sodium chloride solution, after GSK's patent expired on December 24, 2006.

Ondansetron Uses

It's 5 - hydroxytryptamine (5-HT3) receptor antagonist and efficient antiemetic drug, with high strength and a high degree of selectivity.It can control vomit which stimulate by receptor in the small intestine and the CTZ (chemoreceptor launch center).  

Ondansetron Toxicity Data With Reference

1.    

ivn-man TDLo:229 µg/kg/I

    LANCAO    Lancet. 344 (1994),190.
2.    

ivn-rat LDLo:20 mg/kg

    SOLGAV    Seminars in Oncology. 19 (Suppl 10)(1992),53.
3.    

ivn-mus LDLo:2500 µg/kg

    SOLGAV    Seminars in Oncology. 19 (Suppl 10)(1992),53.
4.    

ivn-dog LD:>10 mg/kg

    SOLGAV    Seminars in Oncology. 19 (Suppl 10)(1992),53.

Ondansetron Safety Profile

A poison by intravenous route. Human systemic effects by intravenous route: jaundice. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes: ToxicTIrritantXi
Risk Statements
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin .
Safety Statements
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39: Wear suitable gloves and eye/face protection .
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: FE6375500

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