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Name |
Proflavine |
EINECS | 202-172-4 (Proflavine) |
CAS No. | 92-62-6 | Density | 1.346 g/cm3 |
PSA | 64.93000 | LogP | 3.71480 |
Solubility | Slightly soluble SOLVENT | Melting Point |
260 C
|
Formula | C13H11 N3 | Boiling Point | 506.9 °C at 760 mmHg |
Molecular Weight | 209.25 | Flash Point | 292.9 °C |
Transport Information | 307 | Appearance | orange to brown powder |
Safety | Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also 2,6-DIAMINOACRIDINE; 3,6-DIAMINOACRIDINE HYDROCHLORIDE HEMIHYDRATE; 3,6-DIAMINOACRIDINE SULFATE (1:1). | Risk Codes | N/A |
Molecular Structure | Hazard Symbols | 9 (Packing Group: III) UN NO. | |
Synonyms |
Acridine,3,6-diamino- (8CI); 3,6-Diaminoacridine; 3,7-Diamino-5-azaanthracene; Isoflavbase; Proflavin; Proflavine |
Article Data | 16 |
Conditions | Yield |
---|---|
With glycerol at 155℃; |
3,6-diaminoacridin-9(10H)-one
proflavine
Conditions | Yield |
---|---|
With sodium hydroxide; sodium amalgam; water |
4,4'-methylenebis(m-nitroaniline)
proflavine
Conditions | Yield |
---|---|
With hydrogenchloride; tin at 135 - 140℃; |
4,4'-methanediyl-bis-m-phenylenediamine
proflavine
Conditions | Yield |
---|---|
With hydrogenchloride at 170℃; |
oxalic acid
m-phenylenediamine
(E)-3-Ureido-but-2-enoic acid ethyl ester
glycerol
proflavine
Conditions | Yield |
---|---|
at 190℃; |
formic acid
m-phenylenediamine
(E)-3-Ureido-but-2-enoic acid ethyl ester
glycerol
proflavine
Conditions | Yield |
---|---|
at 190℃; |
Conditions | Yield |
---|---|
With oxalic acid; zinc(II) chloride at 190℃; Glycerin; | |
With formic acid; zinc(II) chloride at 190℃; Glycerin; |
Conditions | Yield |
---|---|
at 155℃; |
formic acid-(3-amino-anilide)
m-phenylenediamine dihydrochloride
(E)-3-Ureido-but-2-enoic acid ethyl ester
glycerol
proflavine
Conditions | Yield |
---|---|
at 155℃; |
Conditions | Yield |
---|---|
With hydrogenchloride; formic acid; water |
Chemistry informtion about Proflavine (CAS NO.92-62-6) is:
IUPAC Name: Acridine-3,6-Diamine
Synonyms: Proflavine ; 3,6-Acridinediamine ; 3,6-Aiaminoacridine ; Isoflabase
MF: C13H11N3
MW: 11209.2465
Density: 1.346 g/cm3
Flash Point: 292.9 °C
Boiling Point: 506.9 °C at 760 mmHg
Vapour Pressure: 2.14E-10 mmHg at 25°C
Enthalpy of Vaporization: 77.69 kJ/mol
Following is the molecular structure of Proflavine (CAS NO.92-62-6) is:
3,6-Diaminoacridinium (CAS NO.92-62-6) has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 11111ug/kg (11.111mg/kg) | sense organs and special senses: other changes: olfaction sense organs and special senses: other: eye lungs, thorax, or respiration: other changes | Lancet. Vol. 196, Pg. 838, 1919. |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Chemotherapy Vol. 16, Pg. 371, 1971. | |
mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Journal of Medicinal Chemistry. Vol. 18, Pg. 320, 1975. | |
mouse | LD50 | subcutaneous | 140mg/kg (140mg/kg) | British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947. |
IARC Cancer Review: Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 (1980),p. 195.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also 2,6-DIAMINOACRIDINE; 3,6-DIAMINOACRIDINE HYDROCHLORIDE HEMIHYDRATE; 3,6-DIAMINOACRIDINE SULFATE (1:1).
Proflavine (CAS NO.92-62-6), also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions. Proflavine absorbs strongly in the blue region at 445nm (in water at pH 7) with molar extinction coefficient of c. 40,000.