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Pazopanib

  • Name Pazopanib
  • EINECSN/A
  • CAS No. 444731-52-6
  • Density1.40 g/cm3
  • PSA127.41000
  • LogP4.99310
  • SolubilityN/A
  • Melting Point285-289°C (dec.)
  • FormulaC21H23N7O2S
  • Boiling Point728.814 °C at 760 mmHg
  • Molecular Weight437.525
  • Flash Point394.572 °C
  • Transport InformationN/A
  • AppearanceWhite powder
  • Safety36/37/39-28B
  • Risk Codes43-62/63
  • Molecular Structure
    Molecular Structure of 444731-52-6 (Pazopanib)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data7

Pazopanib Specification

Pazopanib, its cas register number 444731-52-6. It also can be called GW786034; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide; Pazopanib; UNII-7RN5DR86CK. Its classification code is Antineoplastic Agents. It belongs to the Intermediates & Fine Chemicals; Pharmaceuticals; HFC80010. Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. And it is used as an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Physical properties about Pazopanib are: (1)ACD/LogP: 3.117; (2)ACD/LogD (pH 5.5): 2.48; (3)ACD/LogD (pH 7.4): 3.10; (4)ACD/BCF (pH 5.5): 32.07; (5)ACD/BCF (pH 7.4): 131.95; (6)ACD/KOC (pH 5.5): 275.29; (7)ACD/KOC (pH 7.4): 1132.61; (8)#H bond acceptors: 9; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.702; (12)Molar Refractivity: 120.188 cm3; (13)Molar Volume: 310.355 cm3; (14)Polarizability: 47.646 10-24cm3; (15)Surface Tension: 56.6650009155273 dyne/cm; (16)Density: 1.41 g/cm3; (17)Flash Point: 394.572 °C; (18)Enthalpy of Vaporization: 106.395 kJ/mol; (19)Boiling Point: 728.814 °C at 760 mmHg;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);
(2)InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;
(3)SmilesCc1ccc(cc1S(=O)(=O)N)Nc2nccc(n2)N(C)c3ccc4c(n(nc4c3)C)C

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