(6-Chloro-pyrimidin-4-yl)-dimethyl-amine

Base Information

• Chemical Name: (6-Chloro-pyrimidin-4-yl)-dimethyl-amine
• CAS No.: 31058-83-0
• Molecular Formula: C6H8ClN3
• Molecular Weight: 157.603
• Hs Code.: 2933599090
• Mol file: 31058-83-0.mol

Synonyms:4-Chloro-6-(dimethylamino)pyrimidine;

Chemical Property of (6-Chloro-pyrimidin-4-yl)-dimethyl-amine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 102-103 °C
• Refractive Index: 1.576
• Boiling Point: 271.407 °C at 760 mmHg
• PKA: 2.83±0.10(Predicted)
• Flash Point: 117.943 °C
• PSA: 29.02000
• Density: 1.253 g/cm³
• LogP: 1.19600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(6-Chloro-pyrimidin-4-yl)-dimethyl-amine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-Chloro-pyrimidin-4-yl)-dimethyl-amine

There total 2 articles about (6-Chloro-pyrimidin-4-yl)-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,6-dichloropyrimidine (1193-21-1) + dimethyl amine (124-40-3) → 6-chloro-N,N-dimethylpyrimidin-4-amine (31058-83-0)

Guidance literature:

With triethylamine; In isopropyl alcohol; Heating;

DOI:10.1016/j.tet.2007.04.063

Reference yield:

→ 6-chloro-N,N-dimethylpyrimidin-4-amine (31058-83-0)

Guidance literature:

4,6-Dichlorpyrimidin, Me2NH/EtOH;

DOI:10.1039/jr9610001298

Reference yield: 71.0%

6-chloro-N,N-dimethylpyrimidin-4-amine (31058-83-0) + rac-3-bromocyclohexene (1521-51-3,113667-32-6) → 6-chloro-2-(cyclohex-2-en-1-yl)-N,N-dimethylpyrimidin-4-amine

Guidance literature:

6-chloro-N,N-dimethylpyrimidin-4-amine; With boron trifluoride diethyl etherate; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere; Schlenk technique;

rac-3-bromocyclohexene; With copper (I) cyanide di(lithium chloride)complex; In tetrahydrofuran; at -45 ℃; for 3h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201301694

upstream raw materials:

4,6-dichloropyrimidine

dimethyl amine

Downstream raw materials:

4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

Refernces

• 1、 Borthwick, Jennifer A.,Alemparte, Carlos,Wall, Ian,Whitehurst, Benjamin C.,Argyrou, Argyrides,Burley, Glenn,De Dios-Anton, Paco,Guijarro, Laura,Monteiro, Maria Candida,Ortega, Fatima,Suckling, Colin J,Pichel, Julia Castro,Cacho, Monica,Young, Robert J.. "Mycobacterium tuberculosis Decaprenylphosphoryl-β- d -ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity". . p. 2557 - 2576. Retrieved 2020/03/31.
• 2、 van der Westhuyzen, Christiaan W.,Rousseau, Amanda L.,Parkinson, Christopher J.. "Effect of substituent structure on pyrimidine electrophilic substitution". . p. 5394 - 5405. Retrieved 2008/01/07.