Benzoic acid, 4-methyl-, 2-acetylphenyl ester

Base Information

• Chemical Name: Benzoic acid, 4-methyl-, 2-acetylphenyl ester
• CAS No.: 4010-26-8
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Hs Code.: 2916399090
• Mol file: 4010-26-8.mol

Synonyms:4-Methyl-benzoesaeure-(2-acetyl-phenylester);4-methyl-benzoic acid-(2-acetyl-phenyl ester);

Chemical Property of Benzoic acid, 4-methyl-, 2-acetylphenyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 3.41680

Purity/Quality:

95% ^*data from raw suppliers

(2-ACETYLPHENYL) 4-METHYLBENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-methyl-, 2-acetylphenyl ester

There total 13 articles about Benzoic acid, 4-methyl-, 2-acetylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 4-methyl-benzoyl chloride (874-60-2) → 2-acetylphenyl-4-methyl benzoate (4010-26-8)

Guidance literature:

With pyridine; at 10 - 20 ℃; for 1h;

DOI:10.1007/s11172-012-0242-z

Reference yield: 80.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-acetylphenyl-4-methyl benzoate (4010-26-8)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In acetonitrile; at 80 ℃; for 15h;

DOI:10.1016/j.tet.2021.132000

Reference yield: 78.0%

4-methyl-benzaldehyde (104-87-0) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-acetylphenyl-4-methyl benzoate (4010-26-8)

Guidance literature:

With tert.-butylhydroperoxide; In water; dimethyl sulfoxide; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.05.113

upstream raw materials:

para-chlorotoluene

o-hydroxyacetophenone

4-methyl-benzoyl chloride

p-Toluic acid

Downstream raw materials:

2-(4'-methylphenyl)-3-methylbenzofuran

2-(4-Dibromomethyl-phenyl)-chromen-4-one

2-(4'-formyl-phenyl)-4H-1-benzopyran-4-one

3-(methoxymethyl)oxy-4'-(bromomethyl)flavone

Refernces

• 1、 Kumar, Upendra,Sharma, Ajay,Kumar, Naveen,Pandey, Satyendra Kumar. "Copper-catalyzed chemoselective oxidative o-aroylation of 2-acetylphenols, alkyl salicylates and 1,3-dicarbonyl compounds using styrene derivatives". . . Retrieved 2021/03/03.
• 2、 Andrade, Josimara Souza,Diogo, Gabriela Maciel,Dos Santos, Viviane Martins Rebello,Murta, Silvane Maria Fonseca,Sales, Policarpo Ademar,Taylor, Jason Guy. "Trypanocidal activity of flavanone derivatives". . . Retrieved 2020/01/28.