2-(4'-methylphenyl)-3-methylbenzofuran

Base Information

• Chemical Name: 2-(4'-methylphenyl)-3-methylbenzofuran
• CAS No.: 204908-14-5
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.287
• Mol file: 204908-14-5.mol

Synonyms:2-(4'-methylphenyl)-3-methylbenzofuran

Chemical Property of 2-(4'-methylphenyl)-3-methylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4'-methylphenyl)-3-methylbenzofuran

There total 9 articles about 2-(4'-methylphenyl)-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-methyl-1-benzofuran-2-carboxylic acid (24673-56-1) + para-bromotoluene (106-38-7) → 2-(4'-methylphenyl)-3-methylbenzofuran (204908-14-5)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetrabutyl-ammonium chloride; caesium carbonate; In N,N-dimethyl-formamide; at 170 ℃; for 0.133333h; Microwave irradiation;

DOI:10.1021/jo9022793

Reference yield: 73.0%

2-acetylphenyl-4-methyl benzoate (4010-26-8) → 2-(4'-methylphenyl)-3-methylbenzofuran (204908-14-5)

Guidance literature:

With titanium(III) chloride; zinc; In tetrahydrofuran; Inert atmosphere; Reflux;

Reference yield: 67.0%

3-methyl-1-benzofuran-2-carboxylic acid (24673-56-1) + p-tolyl triflate (29540-83-8) → 2-(4'-methylphenyl)-3-methylbenzofuran (204908-14-5)

Guidance literature:

With (1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate; potassium tert-butylate; palladium diacetate; In 1-methyl-pyrrolidin-2-one; at 170 ℃; for 1h; Sonication; Continuous flow reactor;

DOI:10.1039/c0cc05708h

upstream raw materials:

3-methylfuran-2-carboxylic acid

3-methyl-1-benzofuran-2-carboxylic acid

para-bromotoluene

p-tolyl triflate

Refernces

• 1、 Miyagi, Kotaro,Moriyama, Katsuhiko,Togo, Hideo. "One-Pot preparation of 2-arylbenzofurans from oximes with diaryliodonium triflate". . p. 2122 - 2136. Retrieved 2015/01/09.
• 2、 Jumbam,Yedwa,Masamba. "Short communication: Titanium-induced synthesis of benzofurans". experimental part. p. 157 - 160. Retrieved 2012/05/20.