3-Fluorophenethyl alcohol

Base Information

• Chemical Name: 3-Fluorophenethyl alcohol
• CAS No.: 52059-53-7
• Molecular Formula: C8H9FO
• Molecular Weight: 140.157
• Hs Code.: 29062990
• Mol file: 52059-53-7.mol

Synonyms:2-(3-Fluorophenyl)ethanol;3-Fluorobenzeneethanol;3-Fluorophenethyl alcohol;

Chemical Property of 3-Fluorophenethyl alcohol

Chemical Property:

• Vapor Pressure: 0.157mmHg at 25°C
• Refractive Index: n20/D 1.509(lit.)
• Boiling Point: 90 ºC (3 mmHg)
• PKA: 14.76±0.10(Predicted)
• Flash Point: 107 ºC
• PSA: 20.23000
• Density: 1.125
• LogP: 1.36050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-(3-Fluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): CXn
• Hazard Codes: C,Xn
• Statements: 36/37/38-21/22-34
• Safety Statements: 26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-Fluorophenethyl alcohol

There total 10 articles about 3-Fluorophenethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3-fluorophenyl)acetic acid (331-25-9) → 2-(3-fluorophenyl)ethanol (52059-53-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jo050464l

Reference yield: 96.0%

1-ethynyl-3-fluoro-benzene (2561-17-3) → 2-(3-fluorophenyl)ethanol (52059-53-7)

Guidance literature:

With [2,2]bipyridinyl; formic acid; (η⁵-cyclopentadienyl) (η⁶-naphthalene)ruthenium hexafluorophosphate; water; In tetrahydrofuran; at 55 ℃; for 48h;

DOI:10.1038/nchem.1799

Reference yield: 95.0%

ammonium chloride + (3-fluorophenyl)acetic acid (331-25-9) → 2-(3-fluorophenyl)ethanol (52059-53-7)

Guidance literature:

upstream raw materials:

(3-fluorophenyl)acetic acid

3-fluorostyrene

oxirane

3-fluorobromobenzene

Downstream raw materials:

1-(2-bromoethyl)-3-fluorobenzene

[2-(3-fluorophenyl)ethoxy]triisopropylsilane

2-fluoro-4-(2-hydroxyethyl)benzoic acid

1-fluoro-3-[2-(methoxymethoxy)ethyl]benzene

Refernces

• 1、 Yang, Hak Kyun,Son, Woo Seung,Lim, Keon Seung,Kim, Gun Hee,Lim, Eun Jeong,Gadhe, Changdev G.,Lee, Jae Yeol,Jeong, Kyu-Sung,Lim, Sang Min,Pae, Ae Nim. "Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain". . p. 1460 - 1471. Retrieved 2018/09/26.
• 2、 Imaeda, Toshihiro,Ono, Koji,Nakai, Kazuo,Hori, Yasunobu,Matsukawa, Jun,Takagi, Terufumi,Fujioka, Yasushi,Tarui, Naoki,Kondo, Mitsuyo,Imanishi, Akio,Inatomi, Nobuhiro,Kajino, Masahiro,Itoh, Fumio,Nishida, Haruyuki. "Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers". . p. 3719 - 3735. Retrieved 2017/06/13.