3-FLUOROPHENETHYL BROMIDE

Base Information

• Chemical Name: 3-FLUOROPHENETHYL BROMIDE
• CAS No.: 25017-13-4
• Molecular Formula: C8H8BrF
• Molecular Weight: 203.054
• Hs Code.: 2903999090
• Mol file: 25017-13-4.mol

Synonyms:1-(2-Bromoethyl)-3-fluorobenzene;2-(3-Fluorophenyl)ethyl bromide;3-(2-Bromoethyl)fluorobenzene;3-Fluorophenethyl bromide;

Chemical Property of 3-FLUOROPHENETHYL BROMIDE

Chemical Property:

• Vapor Pressure: 0.418mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 202.337 °C at 760 mmHg
• Flash Point: 78.798 °C
• PSA: 0.00000
• Density: 1.454 g/cm³
• LogP: 2.76310
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

3-FluorophenethylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-51-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUOROPHENETHYL BROMIDE

There total 8 articles about 3-FLUOROPHENETHYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon tetrabromide (558-13-4) + 2-(3-fluorophenyl)ethanol (52059-53-7) → 1-(2-bromoethyl)-3-fluorobenzene (25017-13-4)

Guidance literature:

With triphenylphosphine; In diethyl ether;

Reference yield: 89.0%

2-(3-fluorophenyl)ethanol (52059-53-7) → 1-(2-bromoethyl)-3-fluorobenzene (25017-13-4)

Guidance literature:

With 1H-imidazole; bromine; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo050464l

Reference yield: 50.0%

dibromofluoromethane (1868-53-7) + spiro[2.4]hepta-4,6-diene (765-46-8) → 1-(2-bromoethyl)-3-fluorobenzene (25017-13-4)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

2-(3-fluorophenyl)ethanol

dibromofluoromethane

spiro[2.4]hepta-4,6-diene

2-(3-trifluoromethylphenyl)-ethyl bromide

Downstream raw materials:

3-(3-fluorophenyl)propionic acid

4-fluoro-(2-azidoethyl)benzene

1-[2-(3-fluoro-phenyl)-ethyl]-1H-pyrazol-4-ylamine

1-(3-fluorophenethyl)-4-nitro-1H-pyrazole

Refernces

• 1、 Galli, Marzia,Fletcher, Catherine J.,Del Pozo, Marc,Goldup, Stephen M.. "Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins". supporting information. p. 5622 - 5626. Retrieved 2016/07/06.
• 2、 -. "DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST". Page/Page column 69. . Retrieved 2008/06/13.