4-Hydroxyphenyl trifluoromethyl sulphone

Base Information

• Chemical Name: 4-Hydroxyphenyl trifluoromethyl sulphone
• CAS No.: 432-84-8
• Molecular Formula: C7H5F3O3S
• Molecular Weight: 226.176
• Hs Code.: 2908999090
• Mol file: 432-84-8.mol

Synonyms:4-trifluoromethylsulphonyl-phenol;4-[(trifluoromethyl)sulfonyl]phenol;4-Trifluormethansulfonyl-phenol;Phenol,4-[(trifluoromethyl)sulfonyl];4-Hydroxyphenyltrifluoromethylsulphone;4-Trifluoromethanesulfonyl-phenol;

Chemical Property of 4-Hydroxyphenyl trifluoromethyl sulphone

Chemical Property:

• Melting Point: 119-120 °C(Solv: water (7732-18-5))
• Boiling Point: 312.0±42.0 °C(Predicted)
• PKA: 6.48±0.13(Predicted)
• PSA: 62.75000
• Density: 1.548±0.06 g/cm3(Predicted)
• LogP: 2.76650

Purity/Quality:

98%min ^*data from raw suppliers

4-[(Trifluoromethyl)sulphonyl]phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxyphenyl trifluoromethyl sulphone

There total 8 articles about 4-Hydroxyphenyl trifluoromethyl sulphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-trifluoromethylthio)phenol (461-84-7) → 4-Hydroxyphenyltrifluoromethylsulphone (432-84-8)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; 1,2-dichloro-ethane; acetonitrile; at 20 ℃; for 22h; Cooling with ice;

Reference yield:

1-nitro-4-(trifluoromethylsulfonyl)benzene (432-87-1) → p-fluorophenyl trifluoromethyl sulfone (944-30-9) + 4-Hydroxyphenyltrifluoromethylsulphone (432-84-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/S0022-1139(00)80343-7

Reference yield:

4-chlorophenyl trifluoromethyl sulfide (407-16-9) → p-fluorophenyl trifluoromethyl sulfone (944-30-9) + 4-Hydroxyphenyltrifluoromethylsulphone (432-84-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0022-1139(00)80343-7

upstream raw materials:

1-nitro-4-(trifluoromethylsulfonyl)benzene

4-chlorophenyl trifluoromethyl sulfide

p-nitrobenzene iodide

p-nitrophenyl trifluoromethyl sulfide

Downstream raw materials:

2,6-dibromo-4-trifluoromethanesulfonyl-phenol

1-methyl-3-[3-methyl-4-(4-trifluoromethanesulfonylphenoxy)phenyl]-1,3,5-triazinane-2,4,6-trione

3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfonyl)phenyl]picolinamide

2-amino-4-((trifluoromethyl)sulfonyl)phenol

Refernces

• 1、 -. "METHOD FOR PRODUCING 4-(TRIFLUOROMETHYLSULFONYL)PHENOL COMPOUND". Paragraph 0048; 0049; 0050; 0051; 0052; 0054; 0055; 0060. . Retrieved 2018/07/29.
• 2、 -. "NOVEL SILANE COMPOUND HAVING SULFONE STRUCTURE". Paragraph 0121. . Retrieved 2017/01/26.