4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE
• CAS No.: 432-87-1
• Molecular Formula: C7H4 F3 N O4 S
• Molecular Weight: 255.174
• Hs Code.: 2904909090
• Mol file: 432-87-1.mol

Synonyms:Sulfone,p-nitrophenyl trifluoromethyl (6CI,7CI,8CI);1-Nitro-4-[(trifluoromethyl)sulfonyl]benzene; 4-Nitrophenyl trifluoromethylsulfone; p-Nitrophenyl trifluoromethyl sulfone

Chemical Property of 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE

Chemical Property:

• PSA: 88.34000
• LogP: 3.49230

Purity/Quality:

98%min ^*data from raw suppliers

4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE

There total 11 articles about 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-nitrophenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate (1146127-11-8) + Langlois reagent (2926-29-6) → 1-nitro-4-(trifluoromethylsulfonyl)benzene (432-87-1)

Guidance literature:

With copper(I) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

Reference yield: 76.0%

2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate (1961266-44-3) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 1-nitro-4-(trifluoromethylsulfonyl)benzene (432-87-1)

Guidance literature:

4-Nitrobenzenesulfonyl chloride; With sodium hydrogencarbonate; sodium sulfite; In water; at 80 ℃; for 4h; Schlenk technique;

2,8-difluoro-5-(trifluoromethyl)-5Hdibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate; In dimethyl sulfoxide; at 25 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2019.151465

Reference yield: 64.0%

p-nitrophenyl trifluoromethyl sulfide (403-66-7) → 1-nitro-4-(trifluoromethylsulfonyl)benzene (432-87-1)

Guidance literature:

With chromium(VI) oxide; at 100 ℃;

DOI:10.1016/S0022-1139(00)80343-7

upstream raw materials:

p-nitrophenyl trifluoromethyl sulfide

C₇H₄F₃N₃O₄S

phenyl trifluoromethylsulfide

p-nitrobenzenesulfonamide

Downstream raw materials:

4-(trifluoromethanesulfonyl)aniline

p-fluorophenyl trifluoromethyl sulfone

4-Hydroxyphenyltrifluoromethylsulphone

p-nitrobenzotrifluoride

Refernces

• 1、 -. "A method of manufacturing a benzene derivative (trifluoromethylsulfonyl)". Paragraph 0071; 0072. . Retrieved 2016/10/08.
• 2、 Cullen, Steven C.,Shekhar, Shashank,Nere, Nandkishor K.. "Cu-catalyzed couplings of aryl iodonium salts with sodium trifluoromethanesulfinate". . p. 12194 - 12201. Retrieved 2014/01/06.