Cyclohexaneoctanoic acid

Base Information

• Chemical Name: Cyclohexaneoctanoic acid
• CAS No.: 4352-56-1
• Molecular Formula: C14H26O2
• Molecular Weight: 226.359
• Mol file: 4352-56-1.mol

Synonyms:

Chemical Property of Cyclohexaneoctanoic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexaneoctanoic acid

There total 8 articles about Cyclohexaneoctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-bromohexanoic acid (4224-70-8) + 2-cyclohexylethylmagnesium bromide → 8-cyclohexyloctanoic acid (4352-56-1)

Guidance literature:

6-bromohexanoic acid; With 1-methyl-pyrrolidin-2-one; tert-butylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

2-cyclohexylethylmagnesium bromide; With buta-1,3-diene; nickel dichloride; In tetrahydrofuran; for 1h; under 760.051 Torr; Inert atmosphere; Cooling with ice;

DOI:10.1002/chem.201204222

Reference yield:

6-cyclohexylidene-hexanoic acid (4354-57-8) → 8-cyclohexyloctanoic acid (4352-56-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pt

2: (i) LiAlH₄, (ii) aq. NaOH

3: aq. HBr, H₂SO₄

4: (i) Na, (ii) aq. KOH, (iii) (decarboxylation)

With sulfuric acid; hydrogen bromide; hydrogen; platinum;

DOI:10.1021/jm00316a001

Reference yield:

(6-cyclohexyl-hexyl)-malonic acid diethyl ester → 8-cyclohexyloctanoic acid (4352-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH-solution

2: 140 °C

With potassium hydroxide;

upstream raw materials:

1-bromo-6-cyclohexyl-hexane

diethyl malonate

6-cyclohexylhexanoic acid

6-cyclohexylhexan-1-ol

Downstream raw materials:

2-Chloro-3-(7-cyclohexyl-heptyl)-[1,4]naphthoquinone

2-Hydroxy-3-(ω-cyclohexylheptyl)-1,4-naphthoquinone

Refernces

• 1、 -. "7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease". . . Retrieved 2008/06/13.