6-CYCLOHEXYL-HEXANOIC ACID

Base Information

• Chemical Name: 6-CYCLOHEXYL-HEXANOIC ACID
• CAS No.: 4354-56-7
• Molecular Formula: C12H22O2
• Molecular Weight: 198.305
• Hs Code.: 2916209090
• Mol file: 4354-56-7.mol

Synonyms:6-cyclohexylhexanoic acid;Cyclohexanehexanoic acid;

Chemical Property of 6-CYCLOHEXYL-HEXANOIC ACID

Chemical Property:

• Vapor Pressure: 8.91E-05mmHg at 25°C
• Melting Point: 34°C
• Refractive Index: 1.4750
• Boiling Point: 316.2°Cat760mmHg
• Flash Point: 152.5°C
• PSA: 37.30000
• Density: 0.968g/cm³
• LogP: 3.60180
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6-cyclohexylhexanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-?Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.

Technology Process of 6-CYCLOHEXYL-HEXANOIC ACID

There total 17 articles about 6-CYCLOHEXYL-HEXANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-bromohexanoic acid (4224-70-8) + cyclohexylmagnesium bromide (931-50-0) → 6-cyclohexylhexanoic acid (4354-56-7)

Guidance literature:

6-bromohexanoic acid; With 1-methyl-pyrrolidin-2-one; tert-butylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

cyclohexylmagnesium bromide; With buta-1,3-diene; nickel dichloride; In tetrahydrofuran; for 1h; under 760.051 Torr; Inert atmosphere; Cooling with ice;

DOI:10.1002/chem.201204222

Reference yield: 19.0%

6-(4-hydroxyphenyl)hexanoic acid (6952-35-8) → 6-cyclohexylhexanoic acid (4354-56-7) + trans-6-(4-hydroxycyclohexyl)hexanoic acid (107228-91-1) + cis-6-(4-hydroxycyclohexyl)hexanoic acid (107228-93-3)

Guidance literature:

With hydrogen; Rh on carbon; In ethanol; for 1.16667h; under 7428.6 Torr; Ambient temperature;

DOI:10.1248/cpb.36.178

Reference yield:

6-cyclohex-1-enyl-hexanoic acid (4132-61-0) → 6-cyclohexylhexanoic acid (4354-56-7)

Guidance literature:

With nickel; at 125 ℃; under 88260.9 Torr; Hydrogenation;

DOI:10.1021/ja01185a004

upstream raw materials:

6-cyclohex-1-enyl-hexanoic acid

bicyclohexyl-2,6,3'-trione

6-cyclohexylidene-hexanoic acid

6-cyclohex-1-enyl-6-hydroxy-hexanoic acid

Downstream raw materials:

2-Hydroxy-3-(ω-cyclohexylheptyl)-1,4-naphthoquinone

8-cyclohexyloctanoic acid

1-bromo-6-cyclohexyl-hexane

2-Benzaminooxy-6-cyclohexyl-hexansaeure-⁽¹⁾

Refernces

• 1、 Okamoto,Watanabe,Morimoto,Imada. "Synthesis, metabolism, and in vitro biological activities of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619)-related compounds". . p. 178 - 189. Retrieved 2007/10/02.