4(1H)-Quinazolinone, 2-(4-nitrophenyl)-

Base Information

• Chemical Name: 4(1H)-Quinazolinone, 2-(4-nitrophenyl)-
• CAS No.: 4765-59-7
• Molecular Formula: C14H9N3O3
• Molecular Weight: 267.244
• Mol file: 4765-59-7.mol

Synonyms:

Chemical Property of 4(1H)-Quinazolinone, 2-(4-nitrophenyl)-

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Quinazolinone, 2-(4-nitrophenyl)-

There total 42 articles about 4(1H)-Quinazolinone, 2-(4-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-nitrobenzaldehdye (555-16-8) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(4-nitrophenyl)-4(3H)-quinazolinone (4765-59-7)

Guidance literature:

With iodine; at 80 ℃; for 0.5h; Ionic liquid;

DOI:10.1080/00397910903318609

Reference yield: 98.0%

isatoic anhydride (118-48-9) + 4-nitrobenzaldehdye (555-16-8) → 2-(4-nitrophenyl)-4(3H)-quinazolinone (4765-59-7)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 100 ℃; for 0.416667h;

DOI:10.1016/j.molcata.2013.04.002

Reference yield: 94.0%

2-Iodobenzoic acid (88-67-5) + 4-nitrobenzamidine hydrochloride (15723-90-7) → 2-(4-nitrophenyl)-4(3H)-quinazolinone (4765-59-7)

Guidance literature:

With 8-quinolinol; sodium hydroxide; copper dichloride; In water; at 20 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

DOI:10.1080/00397911.2018.1533974

upstream raw materials:

2-(4-Nitrobenzamido)benzamide

N-(4-nitro-benzyliden)-anthranilic acid amide

2-(4-nitrophenyl)-3,4-dihydro-5H-1,3,4-benzotriazepin-5-one

anthranilic acid amide

Downstream raw materials:

4-chloro-2-(4-nitrophenyl)quinazoline

N-(4-(4-oxo-3,4-dihydroquinazoline-2-yl)phenyl)acetamide

Refernces

• 1、 Farhid, Hassan,Hajishaabanha, Fatemeh,Rashidi Vahid, Adina,Shaabani, Ahmad,Shaabani, Shabnam. "A bagasse-supported magnetic manganese dioxide nanoparticle: applications in the selective aerobic oxidation of alcohols and one-pot tandem oxidative synthesis of quinazolinones". . . Retrieved 2022/01/24.
• 2、 Dilebo, Kabelo B.,Gumede, Njabulo J.,Mampa, Richard M.,Mangokoana, Dikgale,Matsebatlela, Thabe M.,Moraone, Ngaoko R.,Nxumalo, Winston,Omondi, Bernard. "Synthesis, in vitro cytotoxic, anti-Mycobacterium tuberculosis and molecular docking studies of 4-pyridylamino- and 4-(ethynylpyridine)quinazolines". . . Retrieved 2021/07/09.