4-Piperidinol,1-(2-fluoroethyl)-(9CI)

Base Information

• Chemical Name: 4-Piperidinol,1-(2-fluoroethyl)-(9CI)
• CAS No.: 492446-45-4
• Molecular Formula: C7H14FNO
• Molecular Weight: 147.193
• Hs Code.: 2933399990
• Mol file: 492446-45-4.mol

Synonyms:PC3464;

Chemical Property of 4-Piperidinol,1-(2-fluoroethyl)-(9CI)

Chemical Property:

• Vapor Pressure: 0.00811mmHg at 25°C
• Boiling Point: 237.2oC at 760 mmHg
• PKA: 14.84±0.20(Predicted)
• Flash Point: 97.3oC
• PSA: 23.47000
• Density: 1.07g/cm3
• LogP: 0.35050
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

≥90.0% ^*data from raw suppliers

1-(2-Fluoroethyl)-4-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinol,1-(2-fluoroethyl)-(9CI)

There total 1 articles about 4-Piperidinol,1-(2-fluoroethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + trifluoromethanesulfonic acid 2-fluoroethyl ester (95353-04-1) → 1-(2-fluoroethyl)piperidin-4-ol (492446-45-4)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 12h;

Reference yield: 63.0%

4-fluoro-1-iodobenzene (352-34-1) + 1-(2-fluoroethyl)piperidin-4-ol (492446-45-4) → 1-(2-fluoroethyl)-4-(4-iodophenoxy)piperidine (1430471-88-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 - 85 ℃; for 72h; Inert atmosphere;

Reference yield: 57.6%

1-(2-fluoroethyl)piperidin-4-ol (492446-45-4) + p-toluenesulfonyl chloride (98-59-9) → 1-(2-fluoroethyl)piperidin-4-yl 4-methylbenzenesulfonate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;

upstream raw materials:

4-HYDROXYPIPERIDINE

trifluoromethanesulfonic acid 2-fluoroethyl ester

Downstream raw materials:

1-(2-fluoroethyl)-4-(4-iodophenoxy)piperidine

Refernces