Bis(4-hydroxyphenyl)disulfide

Base Information

• Chemical Name: Bis(4-hydroxyphenyl)disulfide
• CAS No.: 15015-57-3
• Molecular Formula: C12H10O2S2
• Molecular Weight: 250.342
• Hs Code.: 2930909090
• European Community (EC) Number: 805-758-3
• NSC Number: 132570
• DSSTox Substance ID: DTXSID10299766
• Nikkaji Number: J31.926K
• Wikidata: Q72446040
• ChEMBL ID: CHEMBL558284
• Mol file: 15015-57-3.mol

Synonyms:15015-57-3;Bis(4-hydroxyphenyl)disulfide;Bis(4-hydroxyphenyl) Disulfide;phenol, 4,4'-dithiobis-;4-[(4-hydroxyphenyl)disulfanyl]phenol;4,4'-Dithiodiphenol;4,4'-Dihydroxy diphenyl disulfide;4,4'-disulfanediyldiphenol;4,4'-Dihydroxydiphenyl Disulfide;NSC132570;4,4'-dithiobisphenol;4-hydroxyphenyldisulfide;bis(p-hydroxyphenyl)disulfide;di(4-hydroxyphenyl)-disulfide;SCHEMBL901003;bis(4-hydroxyphenyl)disulphide;CHEMBL558284;DTXSID10299766;XGKGITBBMXTKTE-UHFFFAOYSA-N;HMS1577A18;AMY25575;CCG-2119;MFCD00020164;STL323480;AKOS022140244;NSC-132570;AS-13448;B3827;CS-0157400;FT-0732159;D81808;EN300-352281;A809013;J-519876

Chemical Property of Bis(4-hydroxyphenyl)disulfide

Chemical Property:

• Vapor Pressure: 2.8E-08mmHg at 25°C
• Melting Point: 150.0 to 154.0 °C
• Refractive Index: 1.752
• Boiling Point: 437.9 °C at 760 mmHg
• PKA: 9.01±0.26(Predicted)
• Flash Point: 212.5 °C
• PSA: 91.06000
• Density: 1.449 g/cm³
• LogP: 3.89720
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 250.01222190
• Heavy Atom Count: 16
• Complexity: 175

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis(4-hydroxyphenyl) Disulfide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)SSC2=CC=C(C=C2)O

Technology Process of Bis(4-hydroxyphenyl)disulfide

There total 19 articles about Bis(4-hydroxyphenyl)disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-sulfanylphenol (637-89-8) → bis(4-hydroxyphenyl)disulfide (15015-57-3)

Guidance literature:

With N-phenyltriazolinedione; In toluene; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.10.134

Reference yield: 90.0%

4-sulfanylphenol (637-89-8) + carbonic acid dimethyl ester (616-38-6) → bis(4-hydroxyphenyl)disulfide (15015-57-3) + 4-hydroxythioanisole (1073-72-9) + 1-methoxy-4-methylsulfanyl-benzene (1879-16-9)

Guidance literature:

With NaY faujasite; at 150 ℃; for 13h;

DOI:10.1021/jo0520792

Reference yield: 78.0%

1-thiopropane (107-03-9) + 4-sulfanylphenol (637-89-8) → bis(4-hydroxyphenyl)disulfide (15015-57-3) + C9H12OS2 + Dipropyl disulfide (629-19-6)

Guidance literature:

With 4,6-di-tert-butyl-N-(tert-butyl)-o-aminophenol; In acetonitrile; at 20 ℃; for 4h; Electrochemical reaction;

DOI:10.1149/1945-7111/abfe43

upstream raw materials:

p-diazophenol

4-thiocyanato-phenol

4-sulfanylphenol

phenol

Downstream raw materials:

bis(p-tert-butoxyphenyl) disulfide

C₁₂H₁₀O₂S₂*C₆H₄O₂

4-phenylsulfanylphenol

methyl 2-{4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetate

Refernces

• 1、 Tan, Kheng Yee Desmond,Kee, Jun Wei,Fan, Wai Yip. "CpMn(CO)3-catalyzed photoconversion of thiols into disulfides and dihydrogen". . p. 4459 - 4463. Retrieved 2010.
• 2、 Iida, Hiroki,Kozako, Ryo,Oka, Marina. "Green Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis". supporting information. p. 1227 - 1230. Retrieved 2021/06/21.
• 3、 -. "Preparation method of symmetric disulfide bond-containing compound". Paragraph 0020; 0048-0050. . Retrieved 2021/11/21.