Methanone, (4-methoxyphenyl)-4-quinazolinyl-

Base Information

• Chemical Name: Methanone, (4-methoxyphenyl)-4-quinazolinyl-
• CAS No.: 55326-10-8
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• ChEMBL ID: CHEMBL3425558
• DSSTox Substance ID: DTXSID20480163
• Nikkaji Number: J463.560D
• Wikidata: Q82314754
• Mol file: 55326-10-8.mol

Synonyms:55326-10-8;Methanone, (4-methoxyphenyl)-4-quinazolinyl-;CHEMBL3425558;DTXSID20480163

Chemical Property of Methanone, (4-methoxyphenyl)-4-quinazolinyl-

Chemical Property:

• PSA: 52.08000
• LogP: 2.86940
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 264.089877630
• Heavy Atom Count: 20
• Complexity: 339

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=NC=NC3=CC=CC=C32

Technology Process of Methanone, (4-methoxyphenyl)-4-quinazolinyl-

There total 15 articles about Methanone, (4-methoxyphenyl)-4-quinazolinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloroquinazoline (5190-68-1) + 1,3-dimethyl-2-(α-hydroxy-4-methoxybenzyl)benzimidazolium iodide → (4-methoxyphenyl)(quinazolin-4-yl)methanone (55326-10-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.3987/COM-96-S40

Reference yield: 92.0%

4-chloroquinazoline (5190-68-1) + 4-methoxy-benzaldehyde (123-11-5) → (4-methoxyphenyl)(quinazolin-4-yl)methanone (55326-10-8)

Guidance literature:

With sodium hydride; 1,3-dimethylimidazolim iodide; In 1,4-dioxane; for 0.5h; Heating;

DOI:10.1248/cpb.42.2017

Reference yield: 91.0%

quinazoline (253-82-7) + p-methoxybenzoylformic acid (7099-91-4) → (4-methoxyphenyl)(quinazolin-4-yl)methanone (55326-10-8)

Guidance literature:

With ammonium peroxydisulfate; In water; dimethyl sulfoxide; at 30 ℃; for 16h; Sealed tube;

DOI:10.1021/acs.orglett.9b02679

upstream raw materials:

4-chloroquinazoline

4-methoxy-benzaldehyde

Benzoic acid (4-methoxy-phenyl)-quinazolin-4-yl-methyl ester

1-Methylbenzimidazole

Downstream raw materials:

1-(4-methoxyphenyl)-2-phenyl-1-(quinazoline-4-yl)ethanol

4-(4'-methoxyphenyl)quinazoline

1-(4-methoxyphenyl)ethanone

quinazoline

Refernces

• 1、 Kuroiwa, Kenta,Ishii, Hirosuke,Matsuno, Kenji,Asai, Akira,Suzuki, Yumiko. "Synthesis and structure-activity relationship study of 1-phenyl-1-(quinazolin-4-yl)ethanols as anticancer agents". supporting information. p. 287 - 291. Retrieved 2015/03/30.
• 2、 Miyashita, Akira,Kurachi, Akihito,Matsuoka, Yoshiyuki,Tanabe, Noriko,Suzuki, Yumiko,Iwamoto, Ken-Ichi,Higashino, Takeo. "Synthesis and reactivities of 1,3-dimethyl-2-(α-hydroxy-benzyl)imidazolium and 1,3-dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodides". . p. 417 - 426. Retrieved 2007/10/03.