[R,(-)]-2-Bromobutane

Base Information

• Chemical Name: [R,(-)]-2-Bromobutane
• CAS No.: 5787-33-7
• Molecular Formula: C4H9Br
• Molecular Weight: 137.019
• Mol file: 5787-33-7.mol

Synonyms:Butane, 2-bromo-, (R)-;

Chemical Property of [R,(-)]-2-Bromobutane

Chemical Property:

• Boiling Point: 90.7±8.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 2.17980

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [R,(-)]-2-Bromobutane

There total 18 articles about [R,(-)]-2-Bromobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.1%

(S)-2-butanol (4221-99-2) → (R)-(-)-s-butyl bromide (5787-33-7)

Guidance literature:

With phosphorus tribromide; 1.) 0 deg C, 24 h, 2.) 50 deg C;

DOI:10.1021/jo00271a025

Reference yield:

(S)-2-butanol (4221-99-2) → (S)-2-bromobutane (78-76-2,5787-31-5,5787-33-7,5787-32-6) + (R)-(-)-s-butyl bromide (5787-33-7) + 1,2-bis(diphenylphosphinoyl)ethane (4141-50-8)

Guidance literature:

With bromine; 1,2-bis-(diphenylphosphino)ethane; In dichloromethane; for 0.25h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.3891/acta.chem.scand.52-0778

Reference yield:

(S)-2-butanol (4221-99-2) → (S)-2-bromobutane (78-76-2,5787-31-5,5787-33-7,5787-32-6) + (R)-(-)-s-butyl bromide (5787-33-7) + 1,2-bis(diphenylphosphinoyl)ethane (4141-50-8)

Guidance literature:

With bromine; 1,2-bis-(diphenylphosphino)ethane; In dichloromethane; for 0.25h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.3891/acta.chem.scand.52-0778

upstream raw materials:

(2R)-butan-2-ol

(S)-2-butanol

(R)-(-)-triisopropyl-sec-butyltin

(R)-(-)-diisopropylneopentyl-sec-butyltin

Downstream raw materials:

3-methyl-4-nonanone

2-(2-butyl)quinoxaline

(+)-4-methyl-3-phenylhex-1-ene

(+)-4-methyl-1,1-diphenylhex-1-ene

Refernces

• 1、 Lund, Torben,Jacobsen, Karin Bay. "Complete inversion of configuration in aliphatic nucleophilic substitution reactions with small inner-sphere stabilization". . p. 778 - 783. Retrieved 2007/10/03.
• 2、 Fukuto, Jon M.,Newman, David A.,Jensen, Frederick R.. "Stereochemistries and mechanisms of reactions of electrophiles with organotin compounds". . p. 415 - 420. Retrieved 2008/10/08.