1-ISOCYANATO-3-METHOXYPROPANE

Base Information

• Chemical Name: 1-ISOCYANATO-3-METHOXYPROPANE
• CAS No.: 7019-13-8
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.132
• Hs Code.: 2929109000
• Mol file: 7019-13-8.mol

Synonyms:N-(3-Methoxypropyl)-1-isocyanat;3-Methoxypropyl-isocyanat;3-methoxy-propyl isocyanate;Propane,1-isocyanato-3-methoxy;1-Isocyanato-3-methoxy-propane;

Chemical Property of 1-ISOCYANATO-3-METHOXYPROPANE

Chemical Property:

• Boiling Point: 102 °C(Press: 186 Torr)
• PSA: 38.66000
• Density: 0.95±0.1 g/cm3(Predicted)
• LogP: 0.35870

Purity/Quality:

98%min ^*data from raw suppliers

1-Isocyanato-3-methoxypropane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ISOCYANATO-3-METHOXYPROPANE

There total 5 articles about 1-ISOCYANATO-3-METHOXYPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) → 3-Chloropropyl isocyanate (13010-19-0) + 1-isocyanato-3-methoxy-propane (7019-13-8)

Guidance literature:

With toluene;

Reference yield:

phosgene (75-44-5) + toluene (108-88-3,15644-74-3,16713-13-6) + 3-methoxypropylamine (5332-73-0) → 3-Chloropropyl isocyanate (13010-19-0) + 1-isocyanato-3-methoxy-propane (7019-13-8)

Guidance literature:

das Hydrochlorid reagiert;

Reference yield:

3-methoxypropylamine (5332-73-0) + trichloromethyl chloroformate (503-38-8) → 1-isocyanato-3-methoxy-propane (7019-13-8)

Guidance literature:

With pyrographite; In ethyl acetate; for 5h; Heating;

DOI:10.1021/jm9804376

upstream raw materials:

phosgene

toluene

3-methoxypropylamine

trichloromethyl chloroformate

Downstream raw materials:

N-(3-methoxy-propyl)-N'-(toluene-4-sulfonyl)-urea

(3-benzyl-5-nitro-3H-thiazol-2-ylidene)-(3-methoxy-propyl)-urea

1-(3-Methoxy-propyl)-3-[4-(4-nitro-phenylsulfanyl)-phenyl]-urea

N-(3-methoxy-propyl)-N'-phenyl-urea

Refernces

• 1、 Sasse, Astrid,Kiec-Kononowicz, Katarzyna,Stark, Holger,Motyl, Malgorzata,Reidemeister, Sibylle,Ganellin, C. Robin,Ligneau, Xavier,Schwartz, Jean-Charles,Schunack, Walter. "Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: Synthesis, capillary electrophoresis, and in vitro and oral in vivo activity". . p. 593 - 600. Retrieved 2007/10/03.