13010-19-0 Usage
Description
3-Chloropropyl isocyanate is a clear colorless liquid that is utilized in the synthesis of various organic compounds and pharmaceuticals due to its reactive isocyanate functional group.
Uses
Used in Pharmaceutical Industry:
3-Chloropropyl isocyanate is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its application is primarily due to its reactive isocyanate group, which allows for the formation of carbamates and ureas, which are common structural elements in many drugs.
Used in Chemical Synthesis:
3-Chloropropyl isocyanate is used as a reagent in the synthesis of complex organic molecules. Its application is attributed to its ability to react with various functional groups, facilitating the formation of diverse chemical structures.
Specific Applications:
1. Used in the preparation of 9,10-dimethoxyand 9,10-diethoxy-5H-2,3,7,8,12b,13-hexahydroimidazo[1′,2′:3,4]pyrimido[6,1-a]isoquinolin-5-one.
2. Used in the preparation of 11,12-dimethoxyand 11,12-diethoxy-2H,6H-3,4,8,9,13b,14-hexahydropyrimido[1′,2′:3,4]pyrimido[6,1-a]isoquinoline-6-one.
3. Used in the synthesis of N-[N′-(3-chloropropyl)-N′-nitrosocarbamoyl]-L-proline.
4. Used in the synthesis of 1,3-oxazino[2,3-b]quinazolines via coupling with anthranilamide.
Synthesis Reference(s)
Tetrahedron Letters, 16, p. 695, 1975 DOI: 10.1016/S0040-4039(00)71958-7
Check Digit Verification of cas no
The CAS Registry Mumber 13010-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,1 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13010-19:
(7*1)+(6*3)+(5*0)+(4*1)+(3*0)+(2*1)+(1*9)=40
40 % 10 = 0
So 13010-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H6ClNO/c5-2-1-3-6-4-7/h1-3H2
13010-19-0Relevant articles and documents
Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation
DasGupta, Shirshendu,Murumkar, Prashant R.,Giridhar, Rajani,Yadav, Mange Ram
body text, p. 3604 - 3617 (2009/09/30)
Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.
