(2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone

Base Information

• Chemical Name: (2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone
• CAS No.: 837-58-1
• Molecular Formula: C₁₃H₉Cl₂NO
• Molecular Weight: 266.127
• DSSTox Substance ID: DTXSID20495914
• Nikkaji Number: J370.505F
• Mol file: 837-58-1.mol

Synonyms:837-58-1;(2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone;Methanone, (2-amino-5-chlorophenyl)(4-chlorophenyl)-;SCHEMBL6351799;DTXSID20495914;JBKFVAVNIDDFFD-UHFFFAOYSA-N;AKOS013746052;2-Amino-5-chloro-4'-chloro-benzophenone

Chemical Property of (2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 265.0061193
• Heavy Atom Count: 17
• Complexity: 277

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)C2=C(C=CC(=C2)Cl)N)Cl

Technology Process of (2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone

There total 15 articles about (2-Amino-5-chlorophenyl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-(4-chlorobenzene)-5-chloro-2,1-benzoisoxazole (724-07-2) → 2-amino-4'-chloro-5-chlorobenzophenone (837-58-1,136266-81-4)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1002/hc.20164

Reference yield: 74.0%

4-Cyanochlorobenzene (623-03-0) + 4-chloro-aniline (106-47-8) → 2-amino-4'-chloro-5-chlorobenzophenone (837-58-1,136266-81-4)

Guidance literature:

With gallium(III) trichloride; boron trichloride; In chlorobenzene; at 100 ℃; for 20h;

DOI:10.1016/0040-4039(94)85011-9

Reference yield: 47.0%

5-chloro-2-(4-chlorophenyl)-1H-indole (23746-80-7) → 2-amino-4'-chloro-5-chlorobenzophenone (837-58-1,136266-81-4)

Guidance literature:

With oxygen; caesium carbonate; In dimethyl sulfoxide; at 140 ℃; for 8h;

DOI:10.1002/bkcs.10796

upstream raw materials:

N-(4-chloro-2-(4-chlorobenzoyl)phenyl)acetamide

5-chloro-2-tosylaminobenzoic acid

chlorobenzene

4-Cyanochlorobenzene

Downstream raw materials:

3-acetyl-6-chloro-4-(4-chlorophenyl)quinolin-2(1H)-one

6-chloro-4-(4-chlorophenyl)-3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

4-{3-[6-chloro-4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid

(E)-6-chloro-4-(4-chlorophenyl)-3-[3-(4-chlorophenyl)acryloyl]quinolin-2(1H)-one

Refernces

• 1、 Yu, Jin,Moon, Hye Ran,Min, Beom Kyu,Kim, Jae Nyoung. "2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones". supporting information. p. 893 - 897. Retrieved 2016/06/14.
• 2、 Acker, Timothy M.,Khatri, Alpa,Vance, Katie M.,Slabber, Cathryn,Bacsa, John,Snyder, James P.,Traynelis, Stephen F.,Liotta, Dennis C.. "Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists". . p. 6434 - 6456. Retrieved 2013/09/23.