2-Fluoropropiophenone

Base Information

• Chemical Name: 2-Fluoropropiophenone
• CAS No.: 446-22-0
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Hs Code.: 29147000
• Mol file: 446-22-0.mol

Synonyms:Propiophenone,2'-fluoro- (8CI);1-(2-Fluorophenyl)-1-propanone;2-Fluorophenyl ethyl ketone;ZINC00409283;2'-Fluoropropiophenone;AC1LBAO6;Ethyl 2-Fluorophenyl Ketone;AC1Q2RO4;

Chemical Property of 2-Fluoropropiophenone

Chemical Property:

• Appearance/Colour: Pale yellow oil
• Melting Point: 95-99 °C
• Refractive Index: n20/D 1.5043(lit.)
• Boiling Point: 204.119 °C at 760 mmHg
• Flash Point: 77.067 °C
• PSA: 17.07000
• Density: 1.074 g/cm³
• LogP: 2.22730
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform, Methanol
• Water Solubility.: Soluble in chloroform, methanol. Not miscible in water.

Purity/Quality:

99% ^*data from raw suppliers

2'-Fluoropropiophenone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoropropiophenone (cas# 446-22-0) is a compound useful in organic synthesis.

Technology Process of 2-Fluoropropiophenone

There total 11 articles about 2-Fluoropropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-allyl-2-fluorobenzene (56314-65-9) → 1-(2-fluorophenyl)propan-1-one (446-22-0)

Guidance literature:

With tert.-butylhydroperoxide; palladium diacetate; toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 6h; chemoselective reaction;

DOI:10.1039/c5ob00586h

Reference yield: 85.0%

N-fluorobis(benzenesulfon)imide (133745-75-2) + 1-phenyl-propan-1-one (93-55-0) + lithium diisopropyl amide (4111-54-0) → 1-(2-fluorophenyl)propan-1-one (446-22-0)

Guidance literature:

In tetrahydrofuran;

Reference yield: 54.0%

1-(2-fluorophenyl)-2-propen-1-ol (58824-51-4) → 2-fluoro-1-(2-fluorophenyl)propan-1-one (1340481-59-5) + 1-(2-fluorophenyl)propan-1-one (446-22-0)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Selectfluor; In tetrahydrofuran; at 25 ℃; for 6h; pH=7; regiospecific reaction; aq. phosphate buffer;

DOI:10.1055/s-0030-1260130

upstream raw materials:

2-fluorobenzonitrile

1-(2-fluorophenyl)-1-propanol

2-Fluorobenzaldehyde

N-fluorobis(benzenesulfon)imide

Downstream raw materials:

methyl 2-fluorobenzoate

2-ethyl-2-(2-fluorophenyl)oxirane

1-(2,4-dichlorophenyl)-5-(2-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

1-methyl-2-(N-benzylisopropyl)aminoethyl-2-fluorophenylketone

Refernces

• 1、 -. "Synthesis of 2-fluorocholine aryl carbonyl compounds". . . Retrieved 2017/02/09.
• 2、 Youngsaye, Willmen,Hartland, Cathy L.,Morgan, Barbara J.,Ting, Amal,Nag, Partha P.,Vincent, Benjamin,Mosher, Carrie A.,Bittker, Joshua A.,Dandapani, Sivaraman,Palmer, Michelle,Whitesell, Luke,Lindquist, Susan,Schreiber, Stuart L.,Munoz, Benito. "ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans". supporting information. p. 1501 - 1507. Retrieved 2013/10/22.