Technology Process of [1-({6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl}carbonyl)-6-hydroxy-2,3-dihydro-1H-indol-3-yl]methyl methanesulfonate
There total 10 articles about [1-({6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl}carbonyl)-6-hydroxy-2,3-dihydro-1H-indol-3-yl]methyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
at 24 ℃;
for 20h;
- Guidance literature:
-
With
potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
at 24 ℃;
for 20h;
DOI:10.1021/jo00267a004
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 42 percent / N-bromosuccinimide, H2SO4 / tetrahydrofuran / 10 h / -78 °C
2: 85 percent / dioxane / 10 h / 105 °C
3: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C
4: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C
5: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h
6: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C
7: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr
8: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C
9: 71 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, K2CO3 / dimethylformamide / 20 h / 24 °C
With
hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; hydrogen; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00267a004