1484-26-0Relevant articles and documents
Substituted diarylurea derivative as well as preparation method and application thereof
-
Paragraph 0157-0158; 0160, (2021/08/19)
The invention relates to a substituted diarylurea derivative as well as preparation and application thereof. Specifically, the invention discloses a compound with a formula (I) or an optical isomer, a cis-trans-isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof, wherein the definition of each substituent group in the general formula is described in the specification and claims. The invention further discloses a composition containing the compound and application of the composition. The compound disclosed by the invention has excellent anti-cancer activity on HepG2 liver cancer cells, MGC 803 gastric cancer cells, MCF 7 breast cancer cells and the like, and has a good inhibition effect on the growth of human umbilical vein endothelial cells (HUVEC).
A preparation method of the m-aminophenol
-
Paragraph 0014; 0038-0041, (2019/07/08)
The invention belongs to organic synthesis and chemical raw material preparation technology field, in particular to m-aminophenol of preparation method and its intermediate, m-aminophenol of the preparation method, comprises the steps of: (1) dinitrobenzene substituted with benzyl alcohol produced by the reaction of 1 - benzyloxy - 3 - nitrophenyl; (2) 1 - benzyloxy - 3 - nitrobenzene for filtering of the alkaline inorganic salt the substitution reaction of the liquid catalytic hydrogenation generating m-aminophenol; or, 1 - benzyloxy - 3 - nitrophenyl replace alkaline inorganic salt and filtered out of the reaction solution after the recovery of the solvent is soluble in the organic solvent and then re-dissolved in the solution of the, generated by the catalytic hydrogenation of m-aminophenol. Without intermediate separation and purification processes, direct catalytic hydrogenation "one-pot" process for preparing m-aminophenol; then the re-crystallization or reduced pressure distillation purification of m-aminophenol. The method is simple, mild reaction conditions, equipment strength requirement is low, not generate intermediate waste, environment-friendly, high yield, is suitable for industrial generation.
Enantioselective Visible-Light-Mediated Formation of 3-Cyclopropylquinolones by Triplet-Sensitized Deracemization
Tr?ster, Andreas,Bauer, Andreas,Jandl, Christian,Bach, Thorsten
supporting information, p. 3538 - 3541 (2019/02/01)
3-Allyl-substituted quinolones undergo a triplet-sensitized di-π-methane rearrangement reaction to the corresponding 3-cyclopropylquinolones upon irradiation with visible light (λ=420 nm). A chiral hydrogen-bonding sensitizer (10 mol %) was shown to promote the reaction enantioselectively (88–96 % yield, 32–55 % ee). Surprisingly, it was found that the enantiodifferentiation does not occur at the state of initial product formation but that it is the result of a deracemization event. The individual parameters that control the distribution of enantiomers in the photostationary state have been identified.
