(E)-5-Hydroxy-4-(2-phenylethenyl)-2(5H)-furanone

Base Information

• Chemical Name: (E)-5-Hydroxy-4-(2-phenylethenyl)-2(5H)-furanone
• CAS No.: 91269-98-6
• Molecular Formula: C12H10 O3
• Molecular Weight: 202.21
• UNII: EA2A4GNX48
• Nikkaji Number: J667.418F,J2.496.446I
• Mol file: 91269-98-6.mol

Synonyms:5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone;KYN 54;KYN-54;KYN54

Chemical Property of (E)-5-Hydroxy-4-(2-phenylethenyl)-2(5H)-furanone

Chemical Property:

• Vapor Pressure: 3.44E-09mmHg at 25°C
• Boiling Point: 458.2°Cat760mmHg
• Flash Point: 209.2°C
• PSA: 46.53000
• Density: 1.417g/cm³
• LogP: 1.50140
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

(E)-5-HYDROXY-4-(2-PHENYLETHENYL)-2(5H)-FURANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=CC2=CC(=O)OC2O
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/C2=CC(=O)OC2O

Technology Process of (E)-5-Hydroxy-4-(2-phenylethenyl)-2(5H)-furanone

There total 3 articles about (E)-5-Hydroxy-4-(2-phenylethenyl)-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C18H24O3Si (958300-38-4) → 5-hydroxy-4-<2-phenyl-(E)-ethenyl>-2(5H)-furanone (91269-98-6)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

DOI:10.1248/cpb.55.1365

Reference yield: 45.0%

(2Z,4E)-3-Dimethoxymethyl-5-phenyl-penta-2,4-dienoic acid methyl ester (111455-49-3,111455-59-5) → 5-hydroxy-4-<2-phenyl-(E)-ethenyl>-2(5H)-furanone (91269-98-6)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; water; for 1.5h; Heating;

Reference yield:

aqueous sodium chloride + diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 3-dimethoxymethyl-5-phenyl-2,4-pentadiethylcarboxylic acid ethyl ester + Pyruvic aldehyde dimethyl acetal (6342-56-9) + di-isopropyl ether (108-20-3) + 1,1-dimethoxy-4-phenyl-3-buten-2-one (55980-64-8) → 5-hydroxy-4-<2-phenyl-(E)-ethenyl>-2(5H)-furanone (91269-98-6)

Guidance literature:

With sodium hydroxide; sulfuric acid; ammonium chloride; iodine; benzaldehyde; In 1,4-dioxane; methanol; hexane; water; acetone; toluene; benzene;

upstream raw materials:

(2Z,4E)-3-Dimethoxymethyl-5-phenyl-penta-2,4-dienoic acid methyl ester

diethoxyphosphoryl-acetic acid ethyl ester

Pyruvic aldehyde dimethyl acetal

di-isopropyl ether

Refernces

• 1、 -. "Method for treating ulcer". . . Retrieved 2008/06/13.