n-Octadecylformamide

Base Information

• Chemical Name: n-Octadecylformamide
• CAS No.: 32585-06-1
• Molecular Formula: C19H39NO
• Molecular Weight: 297.525
• Hs Code.: 2924199090
• NSC Number: 127419
• DSSTox Substance ID: DTXSID10298996
• Nikkaji Number: J1.844.982J
• Wikidata: Q82041144
• Mol file: 32585-06-1.mol

Synonyms:n-octadecylformamide;32585-06-1;Octadecylformamide;Formamide, N-octadecyl-;NSC127419;SCHEMBL76963;DTXSID10298996;BCP32390;AKOS024338812;NSC-127419;AS-77744

Chemical Property of n-Octadecylformamide

Chemical Property:

• Vapor Pressure: 1.41E-07mmHg at 25°C
• Boiling Point: 429.4°Cat760mmHg
• PKA: 16.39±0.23(Predicted)
• Flash Point: 267.5°C
• PSA: 29.10000
• Density: 0.854g/cm³
• LogP: 7.02070
• XLogP3: 8.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 17
• Exact Mass: 297.303164868
• Heavy Atom Count: 21
• Complexity: 194

Purity/Quality:

99%min ^*data from raw suppliers

N-OCTADECYLFORMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCCCNC=O

Technology Process of n-Octadecylformamide

There total 12 articles about n-Octadecylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formic acid cyanomethyl ester (150760-95-5) + 1-aminooctadecane (124-30-1) → 1-formamidooctadecane (32585-06-1)

Guidance literature:

In dichloromethane; at 50 ℃; for 2h; Inert atmosphere;

DOI:10.1134/S1068162021040166

Reference yield: 91.0%

formic anhydride (1558-67-4) + 1-aminooctadecane (124-30-1) → 1-formamidooctadecane (32585-06-1)

Guidance literature:

In diethyl ether; pentane; at 0 ℃; for 1h;

DOI:10.1039/P19800002657

Reference yield: 77.0%

N-octadecyl-N-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)formamide → 1-formamidooctadecane (32585-06-1)

Guidance literature:

With methanol; at 65 ℃; for 12h; chemoselective reaction; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1002/anie.202100375

upstream raw materials:

sodium formate

octadecylamine hydrochloride

octadecylamine; formate

choline

Downstream raw materials:

n-Octadecanal

octadecane

Refernces

• 1、 Sahoo, Rajata Kumar,Sarkar, Nabin,Nembenna, Sharanappa. "Zinc Hydride Catalyzed Chemoselective Hydroboration of Isocyanates: Amide Bond Formation and C=O Bond Cleavage". supporting information. p. 11991 - 12000. Retrieved 2021/04/19.
• 2、 Waibel,Nickisch,M?hl,Seim,Meier. "A more sustainable and highly practicable synthesis of aliphatic isocyanides". supporting information. p. 933 - 941. Retrieved 2020/02/21.