Ethanone, 1-[1-(2-chlorophenyl)-5-[5-[3-(methylsulfonyl)phenyl]-2-thienyl]-1H-pyraz ol-3-yl]-

Base Information

• Chemical Name: Ethanone, 1-[1-(2-chlorophenyl)-5-[5-[3-(methylsulfonyl)phenyl]-2-thienyl]-1H-pyraz ol-3-yl]-
• CAS No.: 918316-18-4
• Molecular Formula: C22H17ClN2O3S2
• Molecular Weight: 456.974
• Mol file: 918316-18-4.mol

Synonyms:

Chemical Property of Ethanone, 1-[1-(2-chlorophenyl)-5-[5-[3-(methylsulfonyl)phenyl]-2-thienyl]-1H-pyraz ol-3-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[1-(2-chlorophenyl)-5-[5-[3-(methylsulfonyl)phenyl]-2-thienyl]-1H-pyraz ol-3-yl]-

There total 1 articles about Ethanone, 1-[1-(2-chlorophenyl)-5-[5-[3-(methylsulfonyl)phenyl]-2-thienyl]-1H-pyraz ol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazole-3-carboxylic acid methyl ester + methylmagnesium chloride (676-58-4) → 1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanone (918316-18-4) + 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol (918316-16-2)

Guidance literature:

1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazole-3-carboxylic acid methyl ester; methylmagnesium chloride; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃;

Reference yield: 93.0%

1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanone (918316-18-4) → 1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanone oxime

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; water; at 85 ℃; for 11h;

Reference yield: 92.0%

1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanone (918316-18-4) → 1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanol

Guidance literature:

1-[1-(2-chlorophenyl)-5-(5-[3-(methylsulfonyl)phenyl]-2-thienyl)-1H-pyrazol-3-yl]ethanone; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With water; In tetrahydrofuran;

upstream raw materials:

methylmagnesium chloride

Refernces