6-Methoxy-2,3-dimethylquinoxaline

Base Information

• Chemical Name: 6-Methoxy-2,3-dimethylquinoxaline
• CAS No.: 6637-22-5
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.229
• Hs Code.: 2933990090
• European Community (EC) Number: 229-636-9
• NSC Number: 52078
• UNII: 48J9EGN9KE
• DSSTox Substance ID: DTXSID10216594
• Nikkaji Number: J298.025H
• Wikidata: Q83092837
• Mol file: 6637-22-5.mol

Synonyms:6-Methoxy-2,3-dimethylquinoxaline;6637-22-5;2,3-Dimethyl-6-methoxyquinoxaline;48J9EGN9KE;EINECS 229-636-9;NSC-52078;NSC52078;UNII-48J9EGN9KE;SCHEMBL10435667;DTXSID10216594;MFCD04038947;NSC 52078;Quinoxaline, 6-methoxy-2,3-dimethyl-;FT-0609703

Chemical Property of 6-Methoxy-2,3-dimethylquinoxaline

Chemical Property:

• Vapor Pressure: 0.00195mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 300.8 °C at 760 mmHg
• Flash Point: 103.5 °C
• PSA: 35.01000
• Density: 1.13 g/cm³
• LogP: 2.25520
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 188.094963011
• Heavy Atom Count: 14
• Complexity: 198

Purity/Quality:

99%, ^*data from raw suppliers

2,3-DIMETHYL-6-METHOXYQUINOXALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C2C=C(C=CC2=N1)OC)C

Technology Process of 6-Methoxy-2,3-dimethylquinoxaline

There total 5 articles about 6-Methoxy-2,3-dimethylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-methoxy-2-nitroaniline (16133-49-6) + 2.3-butanediol (513-85-9) → dimethyl-2,3 methoxy-6 quinoxaline (6637-22-5)

Guidance literature:

With cesiumhydroxide monohydrate; In toluene; at 150 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.catcom.2020.105927

Reference yield: 95.0%

dimethylglyoxal (431-03-8) + 4-methoxy-2-nitroaniline (96-96-8) → dimethyl-2,3 methoxy-6 quinoxaline (6637-22-5)

Guidance literature:

With indium; indium(III) chloride; In methanol; for 1.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2015.01.007

Reference yield: 90.0%

4-methoxy-2-nitroaniline (96-96-8) + 2.3-butanediol (513-85-9) → dimethyl-2,3 methoxy-6 quinoxaline (6637-22-5)

Guidance literature:

With cesiumhydroxide monohydrate; C₁₇H₁₄Br₂CoN₄; In toluene; at 150 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1039/c8cc02366b

upstream raw materials:

dimethylglyoxal

4-methoxy-2-nitroaniline

4-methoxy-1,2-phenylenediamine

2.3-butanediol

Refernces

• 1、 Sun, Kangkang,Li, Dandan,Lu, Guo-Ping,Cai, Chun. "Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts". . p. 373 - 381. Retrieved 2020/12/09.
• 2、 Panja, Dibyajyoti,Paul, Bhaskar,Balasubramaniam, Bhuvaneshwari,Gupta, Raju K.,Kundu, Sabuj. "Application of a reusable Co-based nanocatalyst in alcohol dehydrogenative coupling strategy: Synthesis of quinoxaline and imine scaffolds". . . Retrieved 2020/01/21.