16133-49-6

Basic information

• Product Name: 5-METHOXY-2-NITROANILINE
• Synonyms: 5-Methoxy-2-nitrobenzenamine;6-Nitro-m-anisidine;3-Methoxy-6-nitroaniline;3-Amino-4-nitroanisole 2-Amino-4-methoxy-1-nitrobenzene;3-Amino-4-nitroanisole, 6-Nitro-m-anisidine;Benzenamine, 5-methoxy-2-nitro-;BUTTPARK 148\07-49;3-AMINO-4-NITROANISOLE
• CAS NO: 16133-49-6
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• EINECS: 240-293-4
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Nitro Compounds
• Mol File: 16133-49-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 131°C
• Boiling Point: 337.07°C (rough estimate)
• Flash Point: 168.7 °C
• Appearance: COA
• Density: 1.2089 (estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6010 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• PKA: -0.61±0.25(Predicted)
• CAS DataBase Reference: 5-METHOXY-2-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-NITROANILINE(16133-49-6)
• EPA Substance Registry System: 5-METHOXY-2-NITROANILINE(16133-49-6)

Safety Data

• Hazard Codes: T,Xi
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• Hazardous Substances Data: 16133-49-6(Hazardous Substances Data)

Usage

Uses

5-Methoxy-2-nitrobenzenamine is used in the synthesis of methoxybenzimidazole compounds as inhibitors of PI3K, used in the therapeutic treatment of cancer. Also used in the synthesis of NR2B-selective NMDA receptor antagonists in the treatment of a range of nervous system disorders

InChI:InChI=1/C7H8N2O3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,8H2,1H3

Upstream product

• 4280-28-8 3,4-dinitroanisole 
• 20628-18-6 1-acetamido-5-methoxy-2nitrobenzene 
• 67915-26-8 N-(5-hydroxy-2-nitrophenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 28987-59-9 3-chloro-4-nitroanisole 
• 96-96-8 4-methoxy-2-nitroaniline 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 100-17-4 para-methoxynitrobenzene 
• 67-62-9 O-Methylhydroxylamin 
• 865-47-4 potassium tert-butylate 
• 7664-41-7 ammonia 
• 185428-55-1 (5-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester 
• 536-90-3 m-Anisidine 

Downstream Products

• 100-17-4 para-methoxynitrobenzene 
• 98447-11-1 (methoxy-5' nitro-2' anilino)-6 dimethyl-5,8 isoquinoleine 
• 104503-84-6 5-methoxy-2-nitroazidobenzene 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 176956-26-6 ethyl pyruvate 5-methoxy-2-nitrophenylhydrazone 
• 861025-12-9 2-(5-methoxy-2-nitrophenyl)pyridine 
• 861025-09-4 3-(5-methoxy-2-nitrophenyl)-pyridine 
• 131671-04-0 N-ethoxalyl-5-methoxy-2-nitroaniline 
• 173312-36-2 4-bromo-5-methoxy-2-nitrobenzeneamine 
• 843615-26-9 2-(4-{[(5-Methoxy-2-nitrophenyl)amino]sulfonyl}phenoxy)acetamide 
• 20628-18-6 1-acetamido-5-methoxy-2nitrobenzene 
• 1335246-74-6 4-hydroxy-3-methyl-7-nitro-2-phenylindole 
• 1352196-45-2 3-methyl-4-methoxy-7-nitro-2-phenylindole 
• 75909-74-9 2-Nitro-5-methoxyphenylhydrazine 

Related news

Molecular structure, hydrogen-bonding patterns and topological analysis (QTAIM and NCI) of 5-METHOXY-2-NITROANILINE (cas 16133-49-6) and 5-METHOXY-2-NITROANILINE (cas 16133-49-6) with 2-amino-5-nitropyridine (1:1) co-crystal07/17/2019

In this work, we report an analysis of the molecular structure and the hydrogen-bonding patterns in the crystal structures of 5-methoxy-2-nitroaniline (1) and 5-methoxy-2-nitroaniline with 2-amino-5-nitropyridine (1:1) co-crystal (2). X-ray single crystal diffraction experiments were carried out...detailed

Relevant articles and documents

Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives

A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

Conformationally restricted dynamic supramolecular catalysts for substrate-selective epoxidations

A second generation of a substrate-selective dynamic supramolecular catalytic system consisting of a catalyst part and a receptor part, connected by a hydrogen-bonding motif, has been realized based on rational design. The results from analyses of the equilibrium mixture of the species generated by the components of the first generation system led us to selectively lock the cisoid conformation of the catalyst part to increase the amount of the substrate-selective catalytic cavity in the equilibrium mixture. This was realized by strapping the catalyst part by organic synthesis. This strapping led to an increase in substrate selectivity in the pair-wise competitive epoxidations of pyridyl- vs. phenyl-appended styrenes and pyridyl- vs. phenyl-appended stilbenes of both Z- and E- configuration compared to the first generation system, reaching 3.4:1 as the highest substrate selectivity for Z-mono-pyridyl-stilbene (27a) vs. the corresponding all-carbon analogue (28a) and for E-dipyridyl-stilbene (26b) vs. the corresponding all-carbon analogue (28b), respectively.

Triazole Derivatives

Novel triazole derivatives are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumours.