Technology Process of Benzamide,
N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3,6-dimethoxy-
There total 8 articles about Benzamide,
N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3,6-dimethoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 2.5h;
under 760 Torr;
Ambient temperature;
DOI:10.1021/jm00166a012
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi / 1.) THF, 20 deg C, 2.) Et2O
2: Br2 / dioxane / 1 h / Ambient temperature
3: thionyl chloride, DMF / toluene / 1 h / 60 °C
4: CHCl3 / 0.5 h / 50 °C
5: 13 percent / HCl, BBr3 / CH2Cl2; diethyl ether / 1 h / Ambient temperature
6: 100 percent / H2 / 5percent Pd/C / ethanol / 2.5 h / 760 Torr / Ambient temperature
With
hydrogenchloride; n-butyllithium; thionyl chloride; hydrogen; bromine; boron tribromide; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm00166a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Br2 / dioxane / 1 h / Ambient temperature
2: thionyl chloride, DMF / toluene / 1 h / 60 °C
3: CHCl3 / 0.5 h / 50 °C
4: 13 percent / HCl, BBr3 / CH2Cl2; diethyl ether / 1 h / Ambient temperature
5: 100 percent / H2 / 5percent Pd/C / ethanol / 2.5 h / 760 Torr / Ambient temperature
With
hydrogenchloride; thionyl chloride; hydrogen; bromine; boron tribromide; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm00166a012
