8-Bromo-3-(trifluoromethyl)quinoline

Base Information

• Chemical Name: 8-Bromo-3-(trifluoromethyl)quinoline
• CAS No.: 917251-86-6
• Molecular Formula: C10H5BrF3N
• Molecular Weight: 276.0526
• Mol file: 917251-86-6.mol

Synonyms:Quinoline, 8-bromo-3-(trifluoromethyl)-;

Chemical Property of 8-Bromo-3-(trifluoromethyl)quinoline

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 301.343 °C at 760 mmHg
• Flash Point: 136.048 °C
• Density: 1.658 g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

8-Bromo-3-(trifluoromethyl)quinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromo-3-(trifluoromethyl)quinoline

There total 3 articles about 8-Bromo-3-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-(trifluoromethyl)quinoline (25199-76-2) → 8-bromo-3-(trifluoromethyl)quinoline (917251-86-6) + 5-bromo-3-(trifluoromethyl)quinoline (1239462-41-9)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; at 50 ℃; for 1.5h;

Reference yield: 33.0%

8-bromo-3-iodoquinoline (917251-85-5) + (trifluoromethyl)silane (10112-11-5) → 8-bromo-3-(trifluoromethyl)quinoline (917251-86-6)

Guidance literature:

With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 50 ℃; Inert atmosphere;

DOI:10.1021/jm1000908

Reference yield:

8-bromo-3-iodoquinoline (917251-85-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → 8-bromo-3-(trifluoromethyl)quinoline (917251-86-6)

Guidance literature:

8-bromo-3-iodoquinoline; (trifluoromethyl)trimethylsilane; With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 18h;

With ammonia; water; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

upstream raw materials:

8-bromo-3-iodoquinoline

(trifluoromethyl)trimethylsilane

(trifluoromethyl)silane

3-(trifluoromethyl)quinoline

Refernces

• 1、 -. "INHIBITORS OF JUN N-TERMINAL KINASE". Page/Page column 148. . Retrieved 2010/08/18.