8-Bromo-3-iodoquinoline

Base Information

• Chemical Name: 8-Bromo-3-iodoquinoline
• CAS No.: 917251-85-5
• Molecular Formula: C9H5BrIN
• Molecular Weight: 333.95
• Hs Code.: 2933491090
• Mol file: 917251-85-5.mol

Synonyms:8-Bromo-3-iodoquinoline;Quinoline, 8-broMo-3-iodo-

Chemical Property of 8-Bromo-3-iodoquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.744
• Boiling Point: 375.486 °C at 760 mmHg
• Flash Point: 180.887 °C
• PSA: 12.89000
• Density: 2.154 g/cm³
• LogP: 3.60190
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

8-Bromo-3-iodoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromo-3-iodoquinoline

There total 1 articles about 8-Bromo-3-iodoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

8-bromoquinoline (16567-18-3) → 8-bromo-3-iodoquinoline (917251-85-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In water; acetonitrile; at 80 ℃; for 20h; regioselective reaction;

DOI:10.1039/c5cc04013b

Reference yield: 33.0%

8-bromo-3-iodoquinoline (917251-85-5) + (trifluoromethyl)silane (10112-11-5) → 8-bromo-3-(trifluoromethyl)quinoline (917251-86-6)

Guidance literature:

With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 50 ℃; Inert atmosphere;

DOI:10.1021/jm1000908

Reference yield:

8-bromo-3-iodoquinoline (917251-85-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → 8-bromo-3-(trifluoromethyl)quinoline (917251-86-6)

Guidance literature:

8-bromo-3-iodoquinoline; (trifluoromethyl)trimethylsilane; With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 18h;

With ammonia; water; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

upstream raw materials:

8-bromoquinoline

Downstream raw materials:

8-bromo-3-(trifluoromethyl)quinoline

Refernces

• 1、 Sun, Kai,Lv, Yunhe,Wang, Junjie,Sun, Jingjing,Liu, Lulu,Jia, Mingyang,Liu, Xin,Li, Zhenduo,Wang, Xin. "Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines". supporting information. p. 4408 - 4411. Retrieved 2015/09/28.
• 2、 -. "Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor". Page/Page column 53. . Retrieved 2010/11/25.