3,4-Dichloropicolinamide

Base Information

• Chemical Name: 3,4-Dichloropicolinamide
• CAS No.: 1025720-99-3
• Molecular Formula: C6H4Cl2N2O
• Molecular Weight: 191.017
• Mol file: 1025720-99-3.mol

Synonyms:3,4-DICHLOROPICOLINAMIDE;3,4-Dichloro-2-pyridinecarboxamide

Chemical Property of 3,4-Dichloropicolinamide

Chemical Property:

• Boiling Point: 275 ?C
• Flash Point: 120 ?C
• PSA: 55.98000
• Density: 1.524
• LogP: 2.18760

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloropicolinamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dichloropicolinamide

There total 7 articles about 3,4-Dichloropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-dichloropicolinonitrile (1346167-25-6) → 3,4-dichloropyridine-2-carboxamide (1025720-99-3)

Guidance literature:

With Acetaldehyde oxime; copper(II) oxide; In water; for 2h; Reflux;

DOI:10.1016/j.tetlet.2011.11.075

Reference yield: 76.0%

3,4-dichloropyridine-2-carboxylic acid (959578-03-1) → 3,4-dichloropyridine-2-carboxamide (1025720-99-3)

Guidance literature:

3,4-dichloropyridine-2-carboxylic acid; With thionyl chloride; at 80 ℃; for 1h;

With ammonium hydroxide; In diethyl ether; water; at 0 ℃; Product distribution / selectivity;

Reference yield: 53.9%

3,4-dichloropyridine (55934-00-4) + trimethylsilyl isocyanate (1118-02-1) → 3,4-dichloropyridine-2-carboxamide (1025720-99-3)

Guidance literature:

3,4-dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2.25h;

trimethylsilyl isocyanate; In diethyl ether; hexane; at -78 - 20 ℃; for 3h;

upstream raw materials:

3,4-dichloropyridine

trimethylsilyl isocyanate

3,4-dichloropyridine-2-carboxylic acid

3,4-dichloropicolinonitrile

Downstream raw materials:

4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide

3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)phenoxy)picolinamide

3-chloro-4-(4-(3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)-2-fluorophenoxy)-picolinamide

N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide

Refernces

• 1、 Ma, Xiao-Yun,Lu, Ming. "An improved method for the conversion of nitriles to amides using N,N-disubstituted hydroxylamine". . p. 480 - 483. Retrieved 2011.
• 2、 -. "INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF". . . Retrieved 2019/09/30.
• 3、 -. "Double-[...] compound and its method and use thereof". Paragraph 0590; 0591. . Retrieved 2018/10/11.