1,1-Cyclopropanedimethanol cyclic sulfite

Base Information

• Chemical Name: 1,1-Cyclopropanedimethanol cyclic sulfite
• CAS No.: 153493-52-8
• Molecular Formula: C₅H₈O₄S
• Molecular Weight: 164.182
• Mol file: 153493-52-8.mol

Synonyms:1,1-Cyclopropane dimethanol cyclic sulfite;

Chemical Property of 1,1-Cyclopropanedimethanol cyclic sulfite

Chemical Property:

• Boiling Point: 242.8 °C at 760 mmHg
• Flash Point: 100.6 °C
• Density: 1.51 g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1,1-CYCLOPROPANE DIMETHANOL CYCLIC SULFITE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Cyclopropanedimethanol cyclic sulfite

There total 2 articles about 1,1-Cyclopropanedimethanol cyclic sulfite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5,7-dioxa-6-thia-spiro[2.5]octane 6-oxide (89729-09-9) → 5,7-dioxa-6-thiaspiro[2.5]octane 6,6-dioxide (153493-52-8)

Guidance literature:

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile; at 0 - 20 ℃;

Reference yield:

[1-(hydroxymethyl)cyclopropyl]methanol (39590-81-3) → 5,7-dioxa-6-thiaspiro[2.5]octane 6,6-dioxide (153493-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / 1 h / 0 °C / Inert atmosphere

2: rhodium(III) chloride hydrate; sodium periodate / dichloromethane; acetonitrile; water / 0 - 20 °C

With pyridine; sodium periodate; thionyl chloride; rhodium(III) chloride hydrate; In dichloromethane; water; acetonitrile;

DOI:10.1021/jacs.6b03384

upstream raw materials:

[1-(hydroxymethyl)cyclopropyl]methanol

5,7-dioxa-6-thia-spiro[2.5]octane 6-oxide

Refernces

• 1、 Eno, Meredith S.,Lu, Alexander,Morken, James P.. "Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates". . p. 7824 - 7827. Retrieved 2016/07/11.