Technology Process of diethyl (acetylamino)(5-chloropyridin-2-yl)propanedioate
There total 5 articles about diethyl (acetylamino)(5-chloropyridin-2-yl)propanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl (5-amino-2-pyridyl)-2-acetamidomalonate;
With
hydrogenchloride; sodium nitrite;
In
water;
at -10 - 5 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride; copper dichloride;
In
water;
at 18 - 25 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 45 °C / Inert atmosphere
1.2: 45 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 3863.02 Torr / Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / 2 h / -10 - 5 °C / Inert atmosphere
3.2: 2 h / 18 - 25 °C
With
hydrogenchloride; hydrogen; sodium hydride; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 45 °C / Inert atmosphere
1.2: 45 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 3863.02 Torr / Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / 2 h / -10 - 5 °C / Inert atmosphere
3.2: 2 h / 18 - 25 °C
With
hydrogenchloride; hydrogen; sodium hydride; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; water; N,N-dimethyl-formamide; mineral oil;