BETA-FLUORO-DL-ALANINE

Base Information

• Chemical Name: BETA-FLUORO-DL-ALANINE
• CAS No.: 43163-93-5
• Molecular Formula: C₃H₆FNO₂
• Molecular Weight: 107.085
• Mol file: 43163-93-5.mol

Synonyms:Alanine,3-fluoro-, DL- (8CI);DL-Alanine, 3-fluoro-;3-Fluoro-DL-alanine;Racemicfluoromethylglycine;

Chemical Property of BETA-FLUORO-DL-ALANINE

Chemical Property:

• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.428
• Boiling Point: 266.9 °C at 760 mmHg
• Flash Point: 115.2 °C
• PSA: 63.32000
• Density: 1.302 g/cm³
• LogP: 0.06810
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

3-FLUORO-DL-ALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BETA-FLUORO-DL-ALANINE

There total 32 articles about BETA-FLUORO-DL-ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

β-fluoropyruvic acid sodium salt (2923-22-0) → (R)-3-fluoroalanine (35455-21-1,43163-93-5)

Guidance literature:

With sodium formate; ammonium chloride; NADH; In aq. phosphate buffer; at 25 ℃; for 6h; pH=8.0; Reagent/catalyst; Kinetics; Green chemistry; Enzymatic reaction;

DOI:10.1002/cbic.201700493

Reference yield: 80.0%

3-fluoroalanine (16652-37-2,43163-93-5) → (S)-3-fluoroalanine (35455-20-0,43163-93-5) + (R)-3-fluorolactic acid (3130-92-5)

Guidance literature:

With L-alanine dehydrogenase from Bacillus subtilis; rabbit muscle L-lactate dehydrogenase; NAD; In water; at 25 ℃; pH=7.9; Enzymatic reaction;

DOI:10.1016/S0957-4166(00)00096-3

Reference yield: 73.0%

(2S)-2-benzyloxycarbonylamino-3-fluoropropionic acid (36369-37-6) → (S)-3-fluoroalanine (35455-20-0,43163-93-5)

Guidance literature:

With hydrogen; nickel; In ethanol; for 4h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00334-0

upstream raw materials:

2-benzoylamino-3-fluoro-acrylic acid

L-2-bromo-3-fluoro-propionic acid

β-fluoroalanine methyl ester

fluoropyruvic acid

Downstream raw materials:

(S)-3-fluoroalanine

(R)-3-fluorolactic acid

N-Boc-fluoro-L-alanine

fluoropyruvic acid

Refernces

• 1、 Carpentier, Claudia,Godbout, Rapha?l,Otis, Fran?ois,Voyer, Normand. "Synthesis and use of N-Fmoc-l-fluoroalanine". supporting information. p. 1244 - 1246. Retrieved 2015/03/04.
• 2、 Kobayashi, Jyumpei,Shimizu, Yasuhiro,Mutaguchi, Yuta,Doi, Katsumi,Ohshima, Toshihisa. "Characterization of d-amino acid aminotransferase from Lactobacillus salivarius". . p. 15 - 22. Retrieved 2013/10/22.