2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER

Base Information

• Chemical Name: 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER
• CAS No.: 6065-54-9
• Molecular Formula: C7H12O4
• Molecular Weight: 160.17
• Hs Code.: 2917190090
• Mol file: 6065-54-9.mol

Synonyms:Malonicacid, dimethyl-, dimethyl ester (7CI,8CI);Propanedioic acid, dimethyl-,dimethyl ester (9CI);Dimethyl 2,2-dimethylmalonate;Propanedioic acid,2,2-dimethyl-, 1,3-dimethyl ester;

Chemical Property of 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER

Chemical Property:

• Appearance/Colour: colorless transparent liquid
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: 1.416
• Boiling Point: 168.6 °C at 760 mmHg
• Flash Point: 71.6 °C
• PSA: 52.60000
• Density: 1.06 g/cm³
• LogP: 0.35860
• Storage Temp.: 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

2,2-DimethylmalonicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER

There total 8 articles about 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

malonic acid dimethyl ester (108-59-8) + methyl iodide (74-88-4) → dimethyl dimethylmalonate (6065-54-9) + 2,2-dimethylmalonic acid (595-46-0)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; toluene; for 0.333333h; Ambient temperature;

Reference yield:

(Brommethyl)methylmalonsaeure-dimethylester (73879-59-1) → methyl-malonic acid dimethylester (609-02-9) + dimethyl dimethylmalonate (6065-54-9)

Guidance literature:

With heptamethyl cob(I)yrinate; In methanol; at 20 ℃; for 0.25h; Title compound not separated from byproducts.;

DOI:10.1039/b305782h

Reference yield:

malonic acid dimethyl ester (108-59-8) + methyl iodide (74-88-4) → methyl-malonic acid dimethylester (609-02-9) + dimethyl dimethylmalonate (6065-54-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; toluene; at 18 ℃; for 0.25h; Yield given. Yields of byproduct given;

upstream raw materials:

methanol

carbon monoxide

methacrylic acid methyl ester

malonic acid dimethyl ester

Downstream raw materials:

dimethyl-malonic acid bis-methylamide

methyl 2-methyl-2-(phenylsulfanyl)propionate

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

2,2-dimethylmalonic acid methyl 2-phenylethyl ester

Refernces

• 1、 Darbre, Tamis,Keese, Reinhart,Siljegovic, Vuk,Wolleb-Gygi, Annemarie. "175. Model studies for the coenzyme-B12-catalyzed methylmalonyl→succinyl rearrangement. The importance of hydrophobic peripheral associations". . p. 2100 - 2113. Retrieved 2007/10/03.
• 2、 Consiglio, Giambattista,Kollar, Laszlo,Koelliker, Robert. "Carbonylation (hydroformylation and hydrocarbalkoxylation) and enantioselective carbonylation of some methacrylic acid derivatives". . p. 375 - 383. Retrieved 2007/10/02.