Piperidine, 1-amino-2,2,6,6-tetramethyl-

Base Information

• Chemical Name: Piperidine, 1-amino-2,2,6,6-tetramethyl-
• CAS No.: 6130-92-3
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60210209
• Nikkaji Number: J50.645A
• Wikidata: Q83084805
• Mol file: 6130-92-3.mol

Synonyms:2,2,6,6-tetramethylpiperidin-1-amine;6130-92-3;Piperidine, 1-amino-2,2,6,6-tetramethyl-;BRN 1340996;1-Amino-2,2,6,6-tetramethylpiperidine;1-Piperidinamine, 2,2,6,6-tetramethyl-;5-20-04-00250 (Beilstein Handbook Reference);SCHEMBL2278365;DTXSID60210209;2,2,6,6-Tetramethyl-1-piperidinamine;1-amino-2,2,6,6-tetramethyl-piperidine;LS-114225

Chemical Property of Piperidine, 1-amino-2,2,6,6-tetramethyl-

Chemical Property:

• Vapor Pressure: 0.617mmHg at 25°C
• Refractive Index: 1.4820 (estimate)
• Boiling Point: 187.8°C at 760 mmHg
• Flash Point: 37.5°C
• PSA: 29.26000
• Density: 0.859g/cm³
• LogP: 2.54140
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCC(N1N)(C)C)C

Technology Process of Piperidine, 1-amino-2,2,6,6-tetramethyl-

There total 3 articles about Piperidine, 1-amino-2,2,6,6-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2,6,6-tetramethyl-1-nitrosopiperidine (6130-93-4) → 1-amino-2,2,6,6-tetramethylpiperidine (6130-92-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; dibutyl ether; at 95 ℃; for 4h;

DOI:10.1021/ja00367a020

Reference yield:

2,2,6,6-tetramethyl-piperidine (768-66-1) → 1-amino-2,2,6,6-tetramethylpiperidine (6130-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. HCl; NaNO₂ / 75 - 100 °C

2: 73 percent / LiAlH₄ / dibutyl ether / 3 h / 95 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium nitrite; In dibutyl ether; 1: Nitrosation / 2: Reduction;

DOI:10.1021/jo9918293

Reference yield:

→ 1-amino-2,2,6,6-tetramethylpiperidine (6130-92-3)

Guidance literature:

1-Nitroso-2,2,6,6-tetramethyl-piperidin in W., Zn-Pulver, Zufuegen von wss. Eg. (anfangs unter Kuehlung, zuletzt bei 100grad);

DOI:10.1002/hlca.19620450705

upstream raw materials:

2,2,6,6-tetramethyl-1-nitrosopiperidine

2,2,6,6-tetramethyl-piperidine

Downstream raw materials:

2,6-dimethyl-2-heptene

2,6-dimethyl-1-heptene

Bis-(2,2,6,6-tetramethyl-piperidin-1-yl)-diazene

1,1,3-trimethylcyclohexane

Refernces

• 1、 Lucarini, Marco,Pedulli, Gian Franco,Lazzari, Dario. "EPR properties of two new cyclic phosphinylhydrazyl radicals and of their inclusion complexes with cyclodextrins". . p. 2723 - 2727. Retrieved 2000.
• 2、 Hinsberg, William D.,Schultz, Peter G.,Dervan, Peter B.. "Direct Studies of 1,1-Diazenes. Syntheses, Infrared and Electronic Spectra, and Kinetics of the Thermal Decomposition of N-(2,2,6,6-Tetramethylpiperidyl)nitrene and N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene". . p. 766 - 773. Retrieved 2007/10/02.