1-Amino-4-methylpiperazine

Base Information

• Chemical Name: 1-Amino-4-methylpiperazine
• CAS No.: 6928-85-4
• Molecular Formula: C5H13N3
• Molecular Weight: 115.178
• Hs Code.: 29335995
• European Community (EC) Number: 230-053-7
• NSC Number: 80649
• UNII: J5GBT1LFT2
• DSSTox Substance ID: DTXSID3057808
• Nikkaji Number: J38.964A
• Wikidata: Q72439266
• ChEMBL ID: CHEMBL3560514
• Mol file: 6928-85-4.mol

Synonyms:1-amino 4-methylpiperazine;1-amino-4-methylpiperazine

Chemical Property of 1-Amino-4-methylpiperazine

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 1.29hPa at 25℃
• Refractive Index: 1.4835-1.4855
• Boiling Point: 172.811 °C at 760 mmHg
• PKA: 7?+-.0.42(Predicted)
• Flash Point: 58.128 °C
• PSA: 32.50000
• Density: 0.991 g/cm³
• LogP: -0.31640
• Storage Temp.: Store at +2°C to +8°C.
• Sensitive.: Air & Light Sensitive
• Solubility.: water: soluble
• Water Solubility.: miscible
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 115.110947427
• Heavy Atom Count: 8
• Complexity: 66.1

Purity/Quality:

99.9% ^*data from raw suppliers

1-Amino-4-methylpiperazine(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Piperazines
• Canonical SMILES: CN1CCN(CC1)N
• Uses: 1-Amino-4-methylpiperazine has been used:in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenolas a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-aminesynthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-aminesynthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-aminesynthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-aminesynthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-aminesynthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine

Technology Process of 1-Amino-4-methylpiperazine

There total 22 articles about 1-Amino-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methyl-4-nitroso-piperazine (16339-07-4) → 1-methyl-piperazine (109-01-3) + N-amino-N'-methylpiperazine (6928-85-4)

Guidance literature:

With carbon dioxide; water; ammonium chloride; zinc; at 35 ℃; for 1.5h; under 1500.15 Torr; Reagent/catalyst; Temperature; Pressure; Autoclave; Green chemistry;

DOI:10.1007/s10593-018-2349-0

Reference yield: 94.0%

1-methyl-4-nitroso-piperazine (16339-07-4) → N-amino-N'-methylpiperazine (6928-85-4)

Guidance literature:

With hydrogen; In dichloromethane; water; at 50 ℃; for 5h; under 37503.8 Torr; Solvent; Autoclave; Green chemistry;

Reference yield: 87.0%

mechlorethamine hydrochloride (55-86-7) → N,N-bis(2-hydrazinoethyl)methylamine + N-amino-N'-methylpiperazine (6928-85-4)

Guidance literature:

With hydrazine hydrate; at 50 ℃; for 2h;

DOI:10.1023/B:COHC.0000044584.57277.c2

upstream raw materials:

1-methyl-4-nitroso-piperazine

mechlorethamine hydrochloride

N-Methyldiethanolamine

4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

Downstream raw materials:

[2-(2-chloro-phenothiazin-10-yl)-ethyl]-(4-methyl-piperazin-1-yl)-amine

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride

C₁₄H₁₈ClF₃N₄O₂S

Refernces

• 1、 -. "Method for synthesizing 1-amino-4-methylpiperazine from chlorosuccinimide, ammonia water and 1-methyl-piperazine in one step". Paragraph 0033-0044. . Retrieved 2021/11/26.
• 2、 Wu, Yachuang,Ding, Xiudong,Yang, Yifeng,Li, Yingxiu,Qi, Yinliang,Hu, Feng,Qin, Mingze,Liu, Yajing,Sun, Lu,Zhao, Yanfang. "Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria". . . Retrieved 2019/10/23.