CAS No.6928-85-4,1-Amino-4-methylpiperazine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	6928-85-4
Name:	1-Amino-4-methylpiperazine
Article Data:	22

Formula:	C₅H₁₃N₃
Molecular Weight:	115.178
Synonyms:	Piperazine,1-amino-4-methyl- (6CI,7CI,8CI);(4-Methylpiperazin-1-yl)amine;1-Methyl-4-aminopiperazine;4-Methyl-1-aminopiperazine;N-Amino-N'-methylpiperazine;N1-Methyl-N4-aminopiperazine;NSC 80649;1-Piperazinamine,4-methyl-;
EINECS:	230-053-7
Density:	0.991 g/cm³
Boiling Point:	172.811 °C at 760 mmHg
Flash Point:	58.128 °C
Solubility:	miscible with water
Appearance:	clear colorless to light yellow liquid
Hazard Symbols:	Xi,Xn
Risk Codes:	36/37/38-20/21/22
Safety:	24/25-36-26
PSA:	32.50000
LogP:	-0.31640

Synthetic route

: 16339-07-4
1-methyl-4-nitroso-piperazine

A: 109-01-3
1-methyl-piperazine

B: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With carbon dioxide; water; ammonium chloride; zinc at 35℃; under 1500.15 Torr; for 1.5h; Reagent/catalyst; Temperature; Pressure; Autoclave; Green chemistry;	A n/a B 96%
With hydrogen In water at 50℃; under 37503.8 Torr; for 5h; Autoclave; Green chemistry;	A n/a B 38%

: 16339-07-4
1-methyl-4-nitroso-piperazine

: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With hydrogen In dichloromethane; water at 50℃; under 37503.8 Torr; for 5h; Solvent; Autoclave; Green chemistry;	94%
With lithium aluminium tetrahydride In diethyl ether for 10h; Heating;	88%
With acetic acid; zinc In water Cooling with ice;	78%

: 55-86-7
mechlorethamine hydrochloride

: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With hydrazine hydrate	87%

: 55-86-7
mechlorethamine hydrochloride

A: N,N-bis(2-hydrazinoethyl)methylamine

B: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With hydrazine hydrate at 50℃; for 2h;	A 2% B 87%

: 105-59-9
N-Methyldiethanolamine

: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / SOCl2 / CHCl3 / 2 h / 20 °C 2: 87 percent / aq. NH2NH2 View Scheme

: 118306-22-2
4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A: 6928-85-4
N-amino-N'-methylpiperazine

B: 4,9-dihydro-1-methyl-4-{[(4-methyl-1-piperazinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

: 118306-21-1
4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A: 6928-85-4
N-amino-N'-methylpiperazine

B: 4,9-dihydro-3-methyl-4-{[(4-methyl-1-piperazinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

: 118306-23-3
4-(chlorocarbonyl)-4,9-dihydro-1,3-dimethyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A: 6928-85-4
N-amino-N'-methylpiperazine

B: 4,9-dihydro-1,3-dimethyl-4-{[(4-methyl-1-piperazinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

: 118306-24-4
3-chloro-4-(chlorocarbonyl)-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A: 6928-85-4
N-amino-N'-methylpiperazine

B: 3-chloro-4,9-dihydro-4-{[(4-methyl-1-piperazinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

: 21223-19-8
CH3N(CH2CH2)2NNH2*BH3

: 7732-18-5
water

A: 6928-85-4
N-amino-N'-methylpiperazine

B: 1333-74-0
hydrogen

C: 11113-50-1
boric acid

Conditions

Conditions	Yield
In water
In water

...Expand

Raw Materials

16339-07-4

7732-18-5

55-86-7

105-59-9

Downstream Products

13292-46-1

Total:119 Page 1 of 4 1 2 3 4 Next>>

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Specification

1. Introduction of 1-Amino-4-methylpiperazine
The 1-Amino-4-methylpiperazine, with the CAS registry number 6928-85-4, is also known as 1-Piperazinamine, 4-methyl-. It belongs to the product categories of Piperaizine; Piperazine Derivates; Building Blocks; Heterocyclic Building Blocks; Piperazines. This chemical's molecular formula is C₅H₁₃N₃ and molecular weight is 115.18. What's more, its systematic name is called 4-Methyl-1-piperazinamine. It should be stored in a cool, dry and well-ventilated place.

2. Properties of 1-Amino-4-methylpiperazine
Physical properties about 1-Amino-4-methylpiperazine are: (1)ACD/LogP: -1.301; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.36; (4)ACD/LogD (pH 7.4): -3.43; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 32.5 Å²; (13)Index of Refraction: 1.495; (14)Molar Refractivity: 33.841 cm³; (15)Molar Volume: 116.143 cm³; (16)Polarizability: 13.416×10^-24cm³; (17)Surface Tension: 35.26 dyne/cm; (18)Density: 0.992 g/cm³; (19)Flash Point: 58.128 °C; (20)Enthalpy of Vaporization: 40.918 kJ/mol; (21)Boiling Point: 172.811 °C at 760 mmHg; (22)Vapour Pressure: 1.31 mmHg at 25 °C

3. Structure Descriptors of 1-Amino-4-methylpiperazine
You can still convert the following datas into molecular structure:
(1) SMILES: NN1CCN(C)CC1
(2) InChI: InChI=1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
(3) InChIKey: RJWLLQWLBMJCFD-UHFFFAOYSA-N

4. Safety Information of 1-Amino-4-methylpiperazine
Hazard Statement(s) H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statement(s) P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

5. Preparation of 1-Amino-4-methylpiperazine
1-Amino-4-methylpiperazine can be prepared by 1-methyl-4-nitroso-piperazine. The reaction occurs with reagent LiAlH₄ and other condition of heating for 10 hours. The yield is 88 %.

1-Amino-4-methylpiperazine can be prepared by 1-methyl-4-nitroso-piperazine.

6. Uses of 1-Amino-4-methylpiperazine
1-Amino-4-methylpiperazine is used as an intermediate of pharmaceutical and for synthesis of antibiotics of rifampicin; (2) it is used to produce other chemicals. For example, it can react with furan-2-carbonyl chloride to get furan-2-carboxylic acid (4-methyl-piperazin-1-yl)-amide. The reaction occurs with solvent benzene and other condition of heating for 1 hour. The yield is 88 %.

1-Amino-4-methylpiperazine can react with furan-2-carbonyl chloride to get furan-2-carboxylic acid (4-methyl-piperazin-1-yl)-amide.

7. Other details of 1-Amino-4-methylpiperazine
When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system. It may cause damage to health by inhalation, in contacting with skin and if swallowed. Therefore, you should wear suitable protective clothing and avoid contacting with skin, eyes. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.