2-Propoxyethanol

Base Information

• Chemical Name: 2-Propoxyethanol
• CAS No.: 2807-30-9
• Deprecated CAS: 83855-85-0
• Molecular Formula: C5H12O2
• Molecular Weight: 104.149
• Hs Code.: 2909 44 00
• European Community (EC) Number: 220-548-6
• ICSC Number: 0607
• UN Number: 1993
• UNII: TF513KWZ2Y
• DSSTox Substance ID: DTXSID1027500
• Nikkaji Number: J21.260A
• Wikidata: Q1371478
• Metabolomics Workbench ID: 130701
• ChEMBL ID: CHEMBL3189002
• Mol file: 2807-30-9.mol

Synonyms:2-propoxyethanol;ethylene glycol monopropyl ether

Chemical Property of 2-Propoxyethanol

Chemical Property:

• Appearance/Colour: oily colourless odourless liquid
• Vapor Pressure: 1.3 mm Hg ( 20 °C)
• Melting Point: -75 °C(lit.)
• Refractive Index: n20/D 1.413(lit.)
• Boiling Point: 148.4 °C at 760 mmHg
• PKA: 14.43±0.10(Predicted)
• Flash Point: 51.2 °C
• PSA: 29.46000
• Density: 0.906 g/cm³
• LogP: 0.40530
• Storage Temp.: Flammables area
• Solubility.: Soluble in water
• Water Solubility.: 100vol% at 20℃[vol%]
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 104.083729621
• Heavy Atom Count: 7
• Complexity: 29.3
• Transport DOT Label: Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

Ethylene Glycol Monopropyl Ether >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 21-36-10
• Safety Statements: 26-36/37-46

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Glycol Ethers (E Series)
• Canonical SMILES: CCCOCCO
• Inhalation Risk: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract. The substance is mildly irritating to the skin. The substance may cause effects on the blood. This may result in lesions of blood cells.
• Effects of Long Term Exposure: The substance defats the skin, which may cause dryness or cracking.

Technology Process of 2-Propoxyethanol

There total 8 articles about 2-Propoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethyl-1,3-dioxolane (2568-96-9) → 2-propoxyethanol (2807-30-9) + 1,2-di-n-propoxyethane (18854-56-3)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethylene glycol; at 200 ℃; for 1h; under 25802.6 Torr; Autoclave; Inert atmosphere;

Reference yield:

oxirane (75-21-8,99932-75-9) + propan-1-ol (71-23-8) → 2-propoxyethanol (2807-30-9)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01313a031

Reference yield:

oxirane (75-21-8,99932-75-9) + sodium n-propoxide (6819-41-6) → 2-propoxyethanol (2807-30-9)

Guidance literature:

DOI:10.1021/ja01671a022

upstream raw materials:

oxirane

propan-1-ol

sodium n-propoxide

1-iodo-propane

Downstream raw materials:

fluoro-acetic acid-(2-propoxy-ethyl ester)

2-chloroethyl propyl ether

[(2-propoxyethoxy)methyl]benzene

1,2-di-n-propoxyethane

Refernces

• 1、 Wormuth, Klaus R.,Kaler, Eric W.. "Microemulsifying Polar Oils". . p. 4855 - 4861. Retrieved 2007/10/02.