3-Methoxybenzhydrazide

Base Information

• Chemical Name: 3-Methoxybenzhydrazide
• CAS No.: 5785-06-8
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 29280000
• European Community (EC) Number: 227-310-0
• UNII: 2VLT2WS4TY
• DSSTox Substance ID: DTXSID60206561
• Nikkaji Number: J150.059G
• Wikidata: Q83080396
• Mol file: 5785-06-8.mol

Synonyms:3-Methoxybenzhydrazide;3-Methoxybenzohydrazide;5785-06-8;m-Anisic hydrazide;m-Anisohydrazide;3-methoxybenzenecarbohydrazide;Benzoic acid, 3-methoxy-, hydrazide;2VLT2WS4TY;MFCD00007601;3-Methoxybenzoic hydrazide;m-Anisoylhydrazine;m-methoxybenzohydrazide;m-Methoxy benzhydrazide;m-anisic acid hydrazide;3-methoxy-benzohydrazide;3-Methoxybenzoylhydrazine;Maybridge1_001276;UNII-2VLT2WS4TY;3-Methoxybenzohydrazide #;m-Anisic hydrazide, 98%;Oprea1_587451;SCHEMBL667723;M-METHOXYBENZOYLHYDRAZIDE;3-methoxy-benzoic acid hydrazide;HMS545B22;M-METHOXYBENZOIC HYDRAZIDE;DTXSID60206561;EINECS 227-310-0;STK399749;AKOS000147530;M-METHOXYBENZOIC ACID HYDRAZIDE;AD-0163;NCGC00339735-01;BP-12488;MS-11462;SY031614;CS-0033852;FT-0635851;AB01332191-02;EN300-1091392;A917615;J-512784;Z58981865;F8881-8180

Chemical Property of 3-Methoxybenzhydrazide

Chemical Property:

• Melting Point: 86-90 °C
• Refractive Index: 1.558
• PKA: 12.21±0.10(Predicted)
• PSA: 64.35000
• Density: 1.178 g/cm³
• LogP: 1.38990
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C(=O)NN
• Uses: m-Anisic hydrazide has been used in the preparation of Schiff base ligands:(5-chlorosalicylaldehyde furan-1-carbohydrazonato) hexamethylphosphoramide dioxomolybdenum (VI) dimethylformamide solvate5-chlorosalicylaldehyde 3-methoxy-benzo hydrazone(5-chlorosalicylaldehyde 3-methoxy-benzylhydrazonato) dimethylsulfoxide dioxomolybdenum (VI)

Technology Process of 3-Methoxybenzhydrazide

There total 8 articles about 3-Methoxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-methoxybenzoate (10259-22-0) → 3-methoxybenzoic hydrazide (5785-06-8)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

Reference yield: 93.0%

methyl 3-methoxybenzoate (5368-81-0) → 3-methoxybenzoic hydrazide (5785-06-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Reflux;

DOI:10.1021/acs.jmedchem.5b00608

Reference yield: 92.0%

N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-3-methoxybenzamide → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + 3-methoxybenzoic hydrazide (5785-06-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

methyl 3-methoxybenzoate

m-anisoyl chloride

3-Methoxybenzoic acid

ethyl 3-methoxybenzoate

Downstream raw materials:

C₁₇H₂₆N₂O₂

C₁₁H₁₃N₃OS

Refernces

• 1、 Lin, Lin,Lin, Guangyao,Zhou, Qingtong,Bathgate, Ross A.D.,Gong, Grace Qun,Yang, Dehua,Liu, Qing,Wang, Ming-Wei. "Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists". supporting information. . Retrieved 2021/03/16.
• 2、 Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun. "Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles". . p. 11572 - 11581. Retrieved 2021/10/12.