Formamide, N-(p-hydroxyphenethyl)-

Base Information

• Chemical Name: Formamide, N-(p-hydroxyphenethyl)-
• CAS No.: 13062-78-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol file: 13062-78-7.mol

Synonyms:N-Formyltyramine;Formamide,N-(p-hydroxyphenethyl)- (7CI,8CI);Formamide,N-[2-(4-hydroxyphenyl)ethyl]-;

Chemical Property of Formamide, N-(p-hydroxyphenethyl)-

Chemical Property:

• Boiling Point: 420.3 °C at 760 mmHg
• Flash Point: 208 °C
• Density: 1.152 g/cm³

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Formamide, N-(p-hydroxyphenethyl)-

There total 13 articles about Formamide, N-(p-hydroxyphenethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tyrosamine (51-67-2) + Methyl formate (107-31-3) → N-[2-(4-hydroxyphenyl)ethyl]formamide (13062-78-7)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃;

DOI:10.3184/174751915X14402591178530

Reference yield: 96.0%

tyrosamine (51-67-2) + formic acid ethyl ester (109-94-4) → N-[2-(4-hydroxyphenyl)ethyl]formamide (13062-78-7)

Guidance literature:

for 31h; Reflux;

DOI:10.1002/ejoc.201001077

Reference yield: 92.0%

N-{2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethyl}formamide (1521270-08-5) → N-[2-(4-hydroxyphenyl)ethyl]formamide (13062-78-7)

Guidance literature:

With potassium tert-butylate; In water; at 20 ℃; for 8h; Temperature; Reagent/catalyst;

DOI:10.2478/s11696-013-0449-y

upstream raw materials:

tyramine hydrochloride

chloral

tyrosamine

formic acid ethyl ester

Downstream raw materials:

N-{2-[4-(4-nitrophenoxy)phenyl]ethyl}formamide

N-Formyl-2-(4-benzyloxyphenyl)ethylamin

2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine

cannabisin F

Refernces

• 1、 ünver, M. Yagiz,Camacho, Carlos Jamie,D?mling, Alexander,Haupenthal, J?rg,Heine, Andreas,Hirsch, Anna K. H.,Jumde, Varsha R.,Klebe, Gerhard,Konstantinidou, Markella,Magari, Francesca,Sutanto, Fandi. "Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach". supporting information. . Retrieved 2020/04/10.
• 2、 Borase, Bhushan B.,Godbole, Himanshu M.,Singh, Girij P.,Upadhyay, Pritesh R.,Trivedi, Anurag,Bhat, Varadaraj,Shenoy, Gautham G.. "Application of Ugi three component reaction for the synthesis of quinapril hydrochloride". supporting information. p. 48 - 55. Retrieved 2019/11/19.