2-(4-Hydroxyphenyl)ethylazanium;chloride

Base Information

• Chemical Name: 2-(4-Hydroxyphenyl)ethylazanium;chloride
• CAS No.: 60-19-5
• Molecular Formula: C8H12ClNO
• Molecular Weight: 173.642
• Hs Code.: 29222900
• Mol file: 60-19-5.mol

Synonyms:2-(4-hydroxyphenyl)ethylazanium;chloride;Tyraminiumchlorid

Chemical Property of 2-(4-Hydroxyphenyl)ethylazanium;chloride

Chemical Property:

• Appearance/Colour: off-white to light yellow powder
• Vapor Pressure: 0.000123mmHg at 25°C
• Melting Point: 253-255 °C(lit.)
• Refractive Index: 1.577
• Boiling Point: 325.2 °C at 760 mmHg
• Flash Point: 119.2 °C
• PSA: 46.25000
• Density: 1.103 g/cm3
• LogP: 2.39570
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: soluble50 mg/ml, clear, colorless to faintly yellow
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.0607417
• Heavy Atom Count: 11
• Complexity: 87.3

Purity/Quality:

99% ^*data from raw suppliers

Tyramine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC[NH3+])O.[Cl-]
• Uses: Tyramine hydrochloride is a sympathomimetic, the hydrochloride salt of the naturally-occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent but cannot cross the blood-brain barrier. Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.

Technology Process of 2-(4-Hydroxyphenyl)ethylazanium;chloride

There total 22 articles about 2-(4-Hydroxyphenyl)ethylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-cyanomethylphenol (14191-95-8) → tyramine hydrochloride (60-19-5)

Guidance literature:

With hydrogenchloride; 1% Pd/C; hydrogen; In ethanol; water; for 12h; under 2585.81 Torr;

DOI:10.1016/j.tetlet.2008.10.103

Reference yield: 94.0%

1-benzyloxy-4-(2-nitroethenyl)benzene (2982-55-0,169394-83-6) → tyramine hydrochloride (60-19-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 0 ℃; under 760 Torr;

DOI:10.1246/bcsj.63.1252

Reference yield: 85.0%

p-hydroxyphenyl-α-isonitrosoacetophenone → tyramine hydrochloride (60-19-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium; In indication of hydrogen; water;

upstream raw materials:

1-benzyloxy-4-(2-nitroethenyl)benzene

(E)-N-feruloyltyramine

2-[4-(benzyloxy)phenyl]ethylamine hydrochloride

4-<2(E)-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)ethenyl>phenol

Downstream raw materials:

2-(3-bromo-4-hydroxyphenyl)ethylamine

N-acetyltyramine

N-[2-(4-hydroxyphenyl)ethyl]formamide

2,2,2-Trichloro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamidine

Refernces

• 1、 -. "Synthetic method for tyramine hydrochloride". Paragraph 0030; 0033; 0034. . Retrieved 2017/01/31.
• 2、 -. "METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION". Page/Page column 0045; 0056; 0066; 0067. . Retrieved 2014/09/30.