3-(diphenylmethyl)pentanedioic acid

Base Information

• Chemical Name: 3-(diphenylmethyl)pentanedioic acid
• CAS No.: 93878-28-5
• Molecular Formula: C18H18O4
• Molecular Weight: 298.3331
• Mol file: 93878-28-5.mol

Synonyms:

Chemical Property of 3-(diphenylmethyl)pentanedioic acid

Chemical Property:

• Vapor Pressure: 1.01E-08mmHg at 25°C
• Boiling Point: 445.6°Cat760mmHg
• Flash Point: 237.4°C
• Density: 1.234g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(diphenylmethyl)pentanedioic acid

There total 8 articles about 3-(diphenylmethyl)pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

β-Benzhydrylglutaronitrile (94208-72-7) → β-Benzhydrylglutaric acid (93878-28-5)

Guidance literature:

With potassium hydroxide; In ethylene glycol; for 5h; Heating;

DOI:10.1071/CH9951707

Reference yield:

sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) → β-Benzhydrylglutaric acid (93878-28-5)

Guidance literature:

With ethanol; Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts auf 200grad;

DOI:10.1021/ja01864a063

Reference yield:

diethyl 2-benzhydrylmalonate (5292-54-6) → β-Benzhydrylglutaric acid (93878-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / LiAlH₄ / diethyl ether / 3 h / Heating

2: 81 percent / pyridine / 4 h / 0 °C

3: 82 percent / KI / H₂O; dimethylformamide / 4.5 h / 90 °C

4: 82 percent / aq. KOH / ethane-1,2-diol / 5 h / Heating

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; potassium iodide; In diethyl ether; water; ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1071/CH9951707

upstream raw materials:

β-Benzhydrylglutaronitrile

Diphenylacetaldehyde

diethylamine

sodium diethylmalonate

Downstream raw materials:

(+/-)-(trans-1-phenyl-1.2.3.4-tetrahydro-naphthyl-⁽²⁾)-acetic acid

5,8-dimethylbenzo[c]phenanthrene

(4-oxo-1-phenyl-1,2,3,4-tetrahydro-[2]naphthyl)-acetic acid

Refernces