3,4,5-Trimethoxyphenylacetaldehyde

Base Information

• Chemical Name: 3,4,5-Trimethoxyphenylacetaldehyde
• CAS No.: 5320-31-0
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID10201263
• Nikkaji Number: J545.235J
• Wikidata: Q83074435
• Mol file: 5320-31-0.mol

Synonyms:3,4,5-trimethoxyphenylacetaldehyde

Chemical Property of 3,4,5-Trimethoxyphenylacetaldehyde

Chemical Property:

• Vapor Pressure: 0.000497mmHg at 25°C
• Refractive Index: 1.496
• Boiling Point: 313.4 °C at 760 mmHg
• Flash Point: 136.6 °C
• PSA: 44.76000
• Density: 1.097 g/cm³
• LogP: 1.45380
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

98%Min ^*data from raw suppliers

(3,4,5-Trimethoxyphenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)CC=O

Technology Process of 3,4,5-Trimethoxyphenylacetaldehyde

There total 16 articles about 3,4,5-Trimethoxyphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,3-trimethoxy-5-(2-methoxyvinyl)benzene (182217-53-4) → 3,4,5-trimethoxyphenylacetaldehyde (5320-31-0)

Guidance literature:

With hydrogenchloride; In water; acetone; at 25 ℃;

DOI:10.1039/c3ra45933k

Reference yield: 82.0%

5-(epoxyethyl)-1,2,3-tris(methoxy)benzene (54767-81-6) → 3,4,5-trimethoxyphenylacetaldehyde (5320-31-0)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01776

Reference yield: 65.0%

2-(3,4,5-trimethoxyphenyl)ethanol (37785-48-1) → 3,4,5-trimethoxyphenylacetaldehyde (5320-31-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1002/cmdc.201000305

upstream raw materials:

elemicin

3-(3',4',5'-trimethoxyphenyl)-1,2-propanediol

2-(3,4,5-trimethoxyphenyl)ethanol

5-(epoxyethyl)-1,2,3-tris(methoxy)benzene

Downstream raw materials:

1,1,1-Trichloro-3-(3,4,5-trimethoxy-phenyl)-propan-2-ol

C₂₈H₄₂O₆Si

N-(1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethyl)formamide

1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine

Refernces

• 1、 Tian, Guilong,Fedoseev, Pavel,Van der Eycken, Erik V.. "Hypervalent Iodine(III)-Mediated Cascade Cyclization of Propargylguanidines and Total Syntheses of Kealiinine B and C". supporting information. p. 5224 - 5227. Retrieved 2017/04/24.
• 2、 Nguyen, Bichlien H.,Perkins, Robert J.,Smith, Jake A.,Moeller, Kevin D.. "Solvolysis, Electrochemistry, and Development of Synthetic Building Blocks from Sawdust". . p. 11953 - 11962. Retrieved 2016/01/09.