2-FLUOROQUINOLINE

Base Information

• Chemical Name: 2-FLUOROQUINOLINE
• CAS No.: 580-21-2
• Molecular Formula: C9H6FN
• Molecular Weight: 147.152
• Mol file: 580-21-2.mol

Synonyms:2-Fluoroquinoline;

Chemical Property of 2-FLUOROQUINOLINE

Chemical Property:

• Vapor Pressure: 0.0544mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 241.9 °C at 760 mmHg
• PKA: -0.68±0.40(Predicted)
• Flash Point: 100.1 °C
• PSA: 12.89000
• Density: 1.216 g/cm³
• LogP: 2.37390
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROQUINOLINE

There total 8 articles about 2-FLUOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Chloroquinoline (612-62-4) → 2-fluoroquinoline (580-21-2)

Guidance literature:

With 18-crown-6 ether; tetramethlyammonium chloride; cesium fluoride; In acetonitrile; at 60 ℃; for 16h; Glovebox;

DOI:10.1021/acs.joc.0c02845

Reference yield: 83.0%

quinoline (91-22-5) → 2-fluoroquinoline (580-21-2)

Guidance literature:

With silver(II) fluoride; In acetonitrile; at 50 ℃; for 1h; Mechanism;

DOI:10.1126/science.1243759

Reference yield: 77.0%

→ 2-fluoroquinoline (580-21-2)

Guidance literature:

With tetramethylammonium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

upstream raw materials:

2-aminoquinoline

2-Chloroquinoline

quinoline

quinoline-2-carboxylic acid

Downstream raw materials:

2-quinolone

(2-fluoro-3-quinolyl) phenyl ketone

(2-fluoro-3-quinolyl)phenylmethanol

nitrogen trifluoride

Refernces

• 1、 Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang. "Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination". supporting information. p. 4493 - 4498. Retrieved 2021/06/28.
• 2、 -. "METHOD FOR AROMATIC FLUORINATION". Paragraph 0039-0041; 0050. . Retrieved 2018/03/25.