1,1,2,2-Tetrafluoro-1-methoxyethane

Base Information

• Chemical Name: 1,1,2,2-Tetrafluoro-1-methoxyethane
• CAS No.: 425-88-7
• Molecular Formula: C3H4F4O
• Molecular Weight: 132.058
• Hs Code.: 29091990
• European Community (EC) Number: 207-039-4
• DSSTox Substance ID: DTXSID40195282
• Nikkaji Number: J196.103I
• Wikidata: Q66084480
• Mol file: 425-88-7.mol

Synonyms:425-88-7;1,1,2,2-Tetrafluoro-1-methoxyethane;1,1,2,2-Tetrafluoroethyl methyl ether;Methyl 1,1,2,2-tetrafluoroethyl ether;EINECS 207-039-4;Ethane, 1,1,2,2-tetrafluoro-1-methoxy-;Methyl1,1,2,2-tetrafluoroethylether;1-Methoxy-1,1,2,2-tetrafluoroethane;1,1,2,2-tetrafluoro-1-methoxy-ethane;HFE-254pc;SCHEMBL29222;Methyl 2H-Tetrafluoroethyl Ether;YQQHEHMVPLLOKE-UHFFFAOYSA-;DTXSID40195282;HFE-254;MFCD00042106;AKOS005063434;AS-31036;FT-0605968;M2514;J-522646

Chemical Property of 1,1,2,2-Tetrafluoro-1-methoxyethane

Chemical Property:

• Appearance/Colour: Colorless Volatile liquid
• Vapor Pressure: 1280mmHg at 25°C
• Melting Point: -107 °C
• Refractive Index: 1.284
• Boiling Point: 10.1 °C at 760 mmHg
• Flash Point: -20 °C
• PSA: 9.23000
• Density: 1.238 g/cm³
• LogP: 1.49070
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 132.01982740
• Heavy Atom Count: 8
• Complexity: 71.7

Purity/Quality:

99% ^*data from raw suppliers

1,1,2,2-Tetrafluoro-1-methoxyethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi,F+
• Hazard Codes: T,Xi,F+
• Statements: 23/24/25-36/37/38-12-11
• Safety Statements: 36/37/39-45-36-33-26-16-9

MSDS Files:

Useful:

• Canonical SMILES: COC(C(F)F)(F)F

Technology Process of 1,1,2,2-Tetrafluoro-1-methoxyethane

There total 4 articles about 1,1,2,2-Tetrafluoro-1-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

polytetrafluoroethylene (116-14-3,82785-14-6) + sodium methylate (124-41-4) → 1,1,2,2-tetrafluoro-1-methoxyethane (425-88-7)

Guidance literature:

under 14710.2 Torr;

DOI:10.1021/ja01181a526

Reference yield:

methyl hypofluorite (36336-08-0) + 1,1,2-trifluoroethylene (359-11-5) → 1,1,2,2-tetrafluoro-1-methoxyethane (425-88-7) + (1,2,2,2-tetrafluoroethyl)methyl ether (50285-05-7)

Guidance literature:

In [D₃]acetonitrile; at -78 - 20 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0022-1139(02)00163-X

Reference yield:

methanol (67-56-1) + polytetrafluoroethylene (116-14-3,82785-14-6) → 1,1,2,2-tetrafluoro-1-methoxyethane (425-88-7)

Guidance literature:

With sodium methylate;

DOI:10.1016/j.jfluchem.2014.11.001

upstream raw materials:

polytetrafluoroethylene

sodium methylate

methyl hypofluorite

1,1,2-trifluoroethylene

Downstream raw materials:

difluoroacetic acid methyl ester

methylene chloride

difluoroacetyl chloride

2,2-difluoroacetyl fluoride

Refernces

• 1、 Suzuta, Tetsuya,Abe, Takashi,Sekiya, Akira. "Methyl hypofluorite (MeOF) reactions with various fluoroolefins". . p. 3 - 8. Retrieved 2007/10/03.